Lee D A, Topper J E, Brubaker R F
Exp Eye Res. 1984 Mar;38(3):239-46. doi: 10.1016/0014-4835(84)90162-3.
A randomized, double-blind, placebo-controlled study of the effect of topical 0.125% clonidine, a relatively specific alpha 2-adrenergic agonist, on the rate of aqueous humor flow in the eyes of 24 normal human subjects was performed with fluorophotometry. The effect of clonidine on intraocular pressure, anterior chamber volume, pupil size, pulse, and blood pressure was also studied. Clonidine-treated eyes had a 2 mmHg decrease in intraocular pressure which was statistically significant. Fellow placebo-treated eyes had a smaller but significant decrease in pressure. However, between clonidine and fellow placebo-treated eyes, no significant difference was found in intraocular pressure. Aqueous humor flow was 21% lower in clonidine-treated eyes as compared to fellow placebo-treated eyes, 1.9 microliter min-1 as compared to 2.4 microliters min-1. No significant difference was found in anterior chamber volume, blood-aqueous barrier diffusion constant, and apparent resistance between clonidine and fellow placebo-treated eyes. Clonidine produced a significant miosis of 0.4 mm in treated eyes and miosis of 0.2 mm in fellow eyes. Topical 0.125% clonidine significantly decreased systolic blood pressure by 3 mmHg, but did not affect diastolic blood pressure or pulse.
采用荧光光度法对24名正常受试者进行了一项随机、双盲、安慰剂对照研究，以观察局部应用0.125%可乐定（一种相对特异性的α2肾上腺素能激动剂）对眼房水流量的影响。同时还研究了可乐定对眼压、前房容积、瞳孔大小、脉搏和血压的影响。用可乐定治疗的眼睛眼压降低了2 mmHg，具有统计学意义。用安慰剂治疗的对侧眼睛眼压也有较小但显著的降低。然而，在可乐定治疗的眼睛和用安慰剂治疗的对侧眼睛之间，眼压没有显著差异。与用安慰剂治疗的对侧眼睛相比，用可乐定治疗的眼睛房水流量降低了21%，分别为1.9微升/分钟和2.4微升/分钟。在可乐定治疗的眼睛和用安慰剂治疗的对侧眼睛之间，前房容积、血-房水屏障扩散常数和表观阻力没有显著差异。可乐定使治疗眼的瞳孔显著缩小0.4 mm，对侧眼缩小0.2 mm。局部应用0.125%可乐定可使收缩压显著降低3 mmHg，但不影响舒张压或脉搏。
