2-羟烷基-N-亚硝基噻唑烷的致突变性。

Mutagenicity of 2-hydroxyalkyl-N-nitrosothiazolidines.

作者信息

Umano K, Shibamoto T, Fernando S Y, Wei C I

出版信息

Food Chem Toxicol. 1984 Apr;22(4):253-9. doi: 10.1016/0278-6915(84)90002-4.

Abstract

The mutagenicity of 2-hydroxyalkyl-N- nitrosothiazolidines was tested using Salmonella typhimurium strains TA98 and TA100. The N- nitrosothiazolidines tested were unsubstituted N- nitrosothiazolidine (NT), N- nitrosothiazolidine -4-carboxylic acid ( NTC ), 2-hydroxymethyl-N- nitrosothiazolidine ( HMNT ), 2-(1,2,3,4- tetrahydroxybutyl )-N- nitrosothiazolidine , 2-(1,2,3,4- tetrahydroxypentyl )-N- nitrosothiazolidine , 2-(1,2,3,4,5- pentahydroxypentyl )-N- nitrosothiazolidine ( PHPNT ) and 2-(1,2,3,4,5- pentahydroxypentyl )-N- nitrosothiazolidine -4-car boxylic acid. Among the N- nitrosothiazolidines tested, only HMNT and PHPNT exhibited clear dose-response mutagenicity toward strain TA100 with or without metabolic activation. None of the 2-hydroxyalkyl-N- nitrosothiazolidines were mutagenic to strain TA98. NT exhibited much stronger mutagenicity than either HMNT or PHPNT . Mutagenic activities of NT and PHPNT were eliminated by carboxyl substitution in the position alpha to the N-nitroso group.

摘要

使用鼠伤寒沙门氏菌TA98和TA100菌株测试了2-羟烷基-N-亚硝基噻唑烷的致突变性。所测试的N-亚硝基噻唑烷有未取代的N-亚硝基噻唑烷（NT）、N-亚硝基噻唑烷-4-羧酸（NTC）、2-羟甲基-N-亚硝基噻唑烷（HMNT）、2-(1,2,3,4-四羟基丁基)-N-亚硝基噻唑烷、2-(1,2,3,4-四羟基戊基)-N-亚硝基噻唑烷、2-(1,2,3,4,5-五羟基戊基)-N-亚硝基噻唑烷（PHPNT）以及2-(1,2,3,4,5-五羟基戊基)-N-亚硝基噻唑烷-4-羧酸。在所测试的N-亚硝基噻唑烷中，仅HMNT和PHPNT在有或无代谢激活的情况下对TA100菌株表现出明显的剂量反应致突变性。所有2-羟烷基-N-亚硝基噻唑烷对TA98菌株均无致突变性。NT的致突变性比HMNT或PHPNT强得多。N-亚硝基基团α位的羧基取代消除了NT和PHPNT的致突变活性。