Brochier J, Saeland S, Cordier G, Schmitt D
Immunol Lett. 1984;7(5):279-83. doi: 10.1016/0165-2478(84)90035-x.
A monoclonal antibody (MoAb) was selected during a fusion aimed at the preparation of antibodies specific for human T lymphocytes. This antibody reacted against all lymphocytes, but was not specific for the lymphoid lineage because it also detected monocytes, granulocytes and platelets. On skin sections it was found to stain specifically the microfibrillar component of the elastic fibers. This observation illustrates the unexpected specificities often found when making MoAb and, although its significance is still unexplained, provides a unique tool having potential application for anatomy, histopathology, comparative biology and vascular pathology.
在一次旨在制备针对人T淋巴细胞的特异性抗体的融合过程中，筛选出了一种单克隆抗体（MoAb）。这种抗体与所有淋巴细胞发生反应，但并非淋巴细胞系特异性抗体，因为它也能检测到单核细胞、粒细胞和血小板。在皮肤切片上发现它能特异性地染色弹性纤维的微纤维成分。这一观察结果说明了制备单克隆抗体时常常会发现意想不到的特异性，尽管其意义仍未得到解释，但它提供了一种独特的工具，在解剖学、组织病理学、比较生物学和血管病理学方面具有潜在应用价值。
