Gagen M, Gochnour D, Young D, Gaginella T, Neidhart J
J Clin Oncol. 1984 Jun;2(6):696-701. doi: 10.1200/JCO.1984.2.6.696.
In a randomized, crossover design the antiemetic activity of one of the most active single agents, metoclopramide was compared with a combination of dexamethasone and lorazepam. Both regimens were effective, but dexamethasone-lorazepam was significantly better than metoclopramide in preventing (26% versus 13%) or limiting (44% versus 23%) vomiting. Although side effects were more frequent with lorazepam-dexamethasone, the patients generally judged them desirable and overall patient preference was strong (70% versus 12%) for the lorazepam-dexamethasone combination. Patients required supervision and assistance due to lorazepam-induced drowsiness.
在一项随机交叉设计中，将最有效的单一药物之一甲氧氯普胺的止吐活性与地塞米松和劳拉西泮的联合用药进行了比较。两种方案均有效，但地塞米松 - 劳拉西泮在预防（26% 对 13%）或限制（44% 对 23%）呕吐方面明显优于甲氧氯普胺。虽然劳拉西泮 - 地塞米松的副作用更频繁，但患者总体上认为这些副作用是可以接受的，并且患者对劳拉西泮 - 地塞米松联合用药的总体偏好很强（70% 对 12%）。由于劳拉西泮引起的嗜睡，患者需要监督和协助。
