Busch H
Mol Cell Biochem. 1984;61(2):111-30. doi: 10.1007/BF00222490.
Newer methods of identifying biochemical events associated with cancer include recombinant DNA technology, monoclonal antibodies and improved analysis of nuclear and other cell functions to determine specific events which occur commonly in cancer cells. 'Onc-gene' products offer potential opportunities for new approaches to cancer treatment and the hope of inducing differentiation of cancer cells toward their normal counterparts. Studies on antigens which react with monoclonal antibodies offer the opportunity for 'epitope attack' which may be effected by improved drugs or by design of totally new drugs to bind to specific reactive sites. The complexity and pleiomorphism of cancer do not permit predictions as to whether these approaches will be more effective than the empirical approach to cancer treatment.
识别与癌症相关的生化事件的新方法包括重组DNA技术、单克隆抗体以及对细胞核和其他细胞功能进行改进分析，以确定癌细胞中常见的特定事件。“癌基因”产物为癌症治疗的新方法提供了潜在机会，也带来了诱导癌细胞向正常细胞分化的希望。对与单克隆抗体发生反应的抗原进行研究，为“表位攻击”提供了机会，这可以通过改进药物或设计全新药物来结合特定反应位点来实现。癌症的复杂性和多形性使得无法预测这些方法是否会比癌症治疗的经验性方法更有效。
