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肾移植中供体和受体的免疫选择:抗体

[Immunological selection of donors and recipients in renal grafts: antibodies].

作者信息

Seignalet J, Mourad G, Mion C

出版信息

Nephrologie. 1984;5(1):33-9.

PMID:6374486
Abstract

It appears that a wide range of antibodies must be taken into account among future recipients of renal allografts. On one hand, the hazard of hyperacute rejection induced by warm allo-antibodies directed against donor's HLA-A, B antigens is well known. It is probable that warm allo-antibodies directed against donor's Ia (HLA-DR) antigens are also harmful. On the other hand, anti-T or B lymphocytes cold auto-antibodies appear neutral, whereas some studies suggest the possibility of enhancing antibodies which may be anti-idiotypic antibodies.

摘要

在未来肾移植受者中,似乎必须考虑多种抗体。一方面,针对供体HLA - A、B抗原的温性同种异体抗体诱导超急性排斥反应的风险是众所周知的。针对供体Ia(HLA - DR)抗原的温性同种异体抗体也可能具有危害性。另一方面,抗T或B淋巴细胞冷自身抗体似乎是中性的,而一些研究表明存在增强性抗体的可能性,这些抗体可能是抗独特型抗体。

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