Bowring A R, Mackay D, Taylor F R
Pharmatherapeutica. 1984;3(9):613-7.
A double-blind trial was carried out in 62 infants with moderate to severe napkin dermatitis to assess the effectiveness and acceptability of topical treatment with a miconazole/hydrocortisone preparation compared with that of a nystatin/benzalkonium chloride/dimethicone/hydrocortisone preparation. Patients were allocated at random to one or other treatment and the creams were applied to the affected area 3-times daily for 7 days. At the initial visit, a swab was taken for microbiological investigation. Clinical assessments were made of the signs and symptoms of erythema, weeping, tissue maceration and the more general symptom irritability, before and after 7-days' treatment. Parents were asked to note the time taken to significant improvement of their infant's condition and to comment on ease of application and staining properties of the preparation used. Both treatments produced a high and similar overall cure rate (80% and 84%, respectively), with a significant improvement within 48 hours in the majority of cases. Staining of napkins was reported in significantly fewer cases with the miconazole/hydrocortisone cream.
对62例中度至重度尿布皮炎婴儿进行了一项双盲试验，以评估咪康唑/氢化可的松制剂与制霉菌素/苯扎氯铵/二甲基硅油/氢化可的松制剂局部治疗的有效性和可接受性。患者被随机分配接受其中一种治疗，两种乳膏均每日3次涂抹于患处，持续7天。初诊时，采集拭子进行微生物学检查。在治疗7天前后，对红斑、渗液、组织浸渍等体征和症状以及更普遍的烦躁症状进行临床评估。要求家长记录婴儿病情显著改善所需的时间，并对所用制剂的易用性和染色特性进行评价。两种治疗的总体治愈率都很高且相似（分别为80%和84%），大多数病例在48小时内有显著改善。使用咪康唑/氢化可的松乳膏时，尿布染色的病例明显较少。
