Jaffé G V, Grimshaw J J
Pharmatherapeutica. 1986;4(10):628-36.
A double-blind, multi-centre study was carried out in general practice in 76 patients with infected eczema and 43 with impetigo to assess the effectiveness and acceptability of treatment with 1% hydrocortisone plus 0.5% potassium hydroxyquinoline sulphate cream compared with that of 1% hydrocortisone plus 2% miconazole nitrate cream. Patients were allocated at random to receive treatment with one or other preparation, applied twice daily, over a period of 2 weeks. Assessments were made of total symptom severity scores on entry and at the end of each week, as also were bacteriological investigations. The results showed that both combinations produced marked clinical and bacteriological improvement or cure in approximately 90% of patients with infected eczema and the success rate was similar with each preparation. In the case of patients with impetigo, hydrocortisone/potassium hydroxyquinoline sulphate proved significantly more effective than the other combination, the success rates being 92% and 74%, respectively. Patient assessment of the two topical preparations in terms of greasiness, odour and staining showed that, whilst both were considered acceptable by most, there was a trend in favour of the hydrocortisone/potassium hydroxyquinoline sulphate cream. No systemic or local side-effects were reported.
一项双盲、多中心研究在普通医疗环境中开展，纳入了76例感染性湿疹患者和43例脓疱病患者，以评估1%氢化可的松加0.5%硫酸羟基喹啉钾乳膏与1%氢化可的松加2%硝酸咪康唑乳膏治疗的有效性和可接受性。患者被随机分配接受其中一种制剂的治疗，每天涂抹两次，为期2周。在入组时以及每周结束时对总症状严重程度评分进行评估，同时也进行细菌学调查。结果显示，两种组合在约90%的感染性湿疹患者中均产生了显著的临床和细菌学改善或治愈效果，且每种制剂的成功率相似。对于脓疱病患者，氢化可的松/硫酸羟基喹啉钾被证明比另一种组合显著更有效，成功率分别为92%和74%。患者对两种外用制剂在油腻感、气味和染色方面的评估表明，虽然大多数人认为两者均可接受，但有倾向于氢化可的松/硫酸羟基喹啉钾乳膏的趋势。未报告有全身或局部副作用。
