Lendrum R, Walker G, Cudworth A G, Theophanides C, Pyke D A, Bloom A, Gamble D R
Lancet. 1976 Dec 11;2(7998):1273-6. doi: 10.1016/s0140-6736(76)92033-x.
Islet-cell antibodies (I.C.A.) were found in 38% (319/829) of insulin-dependent diabetic patients, in 5% (6/112) of insulin-independent diabetics, and in 1.7% (3/177) of non-diabetic subjects. In the insulin-dependent group I.C.A. were found in 85% of patients immediately after the onset of symptoms and they became less common as the duration of disease increased I.C.A. were equally common in both sexes and the decline in their prevalence was independent of age. The antibodies were directed against cytoplasmic components of islet cells but not against insulin itself. The appearance of I.C.A. probably follows cell damage occurring before the onset of symptoms. By contrast, thyroid and gastric autoantibodies were more common in older patients and females. There was no correlation between the presence of these antibodies and I.C.A. in patients with either diabetes of recent onset or longstanding disease.
在胰岛素依赖型糖尿病患者中，38%（319/829）检测到胰岛细胞抗体（I.C.A.）；在非胰岛素依赖型糖尿病患者中，5%（6/112）检测到该抗体；在非糖尿病受试者中，1.7%（3/177）检测到该抗体。在胰岛素依赖型糖尿病组中，85%的患者在症状出现后立即检测到I.C.A.，随着病程延长，其出现频率降低。I.C.A.在男女中出现频率相同，其患病率下降与年龄无关。这些抗体针对胰岛细胞的细胞质成分，而非胰岛素本身。I.C.A.的出现可能继发于症状出现前发生的细胞损伤。相比之下，甲状腺和胃自身抗体在老年患者和女性中更为常见。在近期发病或病程较长的糖尿病患者中，这些抗体的存在与I.C.A.之间均无相关性。
