Norden C W, Kuller L H
Rev Infect Dis. 1984 Mar-Apr;6(2):200-13. doi: 10.1093/clinids/6.2.200.
Available information regarding possible infectious etiologies of insulin-dependent diabetes mellitus, rheumatoid arthritis, and systemic lupus erythematosus is reviewed. The problems and limitations of classic methods in trying to prove a causal relationship between an infectious agent and a chronic disease are summarized. The authors suggest that these disease occur as a result of persistent infection triggering an immunologic response (which is destructive of host tissue) in genetically susceptible individuals. Prospective studies within families (wherein individuals most at risk for disease can be identified) before the onset or diagnosis of the chronic disease may offer the best approach to elucidating potential infectious etiologies.
本文综述了有关胰岛素依赖型糖尿病、类风湿性关节炎和系统性红斑狼疮可能的感染病因的现有信息。总结了经典方法在试图证明感染因子与慢性疾病之间因果关系时存在的问题和局限性。作者认为，这些疾病是由于持续感染在遗传易感性个体中引发免疫反应（对宿主组织具有破坏性）所致。在慢性疾病发作或诊断之前，对家庭进行前瞻性研究（其中可以识别出疾病风险最高的个体）可能是阐明潜在感染病因的最佳方法。
