• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

胃肠道黏液研究

Studies on gastrointestinal mucus.

作者信息

Allen A, Cunliffe W J, Pearson J P, Sellers L A, Ward R

出版信息

Scand J Gastroenterol Suppl. 1984;93:101-13.

PMID:6374870
Abstract

Mucus is secreted throughout the gastrointestinal tract. The primary secretion is the water insoluble gel adherent to the mucosal surface but substantial amounts of mucus also occur in the lumen. The following are discussed: the functions of mucus; the structure and properties of mucus; study of the adherent mucus gel on the mucosal surface; the effects on mucus properties of proteolysis; thiol agents; bile salts; acid and hyperosmolar solutions. Much of our work on mucus has been with that from the stomach but where possible studies on the intestines and colon are discussed. Studies show that mucous secretions from the different regions of the gastrointestinal tract have similar rheological properties although the component glycoproteins differ in their detailed structure.

摘要

黏液在整个胃肠道中分泌。主要分泌物是附着在黏膜表面的水不溶性凝胶,但大量黏液也存在于管腔中。以下内容将被讨论:黏液的功能;黏液的结构和特性;对黏膜表面附着黏液凝胶的研究;蛋白水解、硫醇试剂、胆汁盐、酸和高渗溶液对黏液特性的影响。我们关于黏液的许多研究工作都集中在胃黏液上,但在可能的情况下也会讨论对小肠和结肠的研究。研究表明,胃肠道不同区域的黏液分泌物具有相似的流变学特性,尽管其组成糖蛋白的详细结构有所不同。

相似文献

1
Studies on gastrointestinal mucus.胃肠道黏液研究
Scand J Gastroenterol Suppl. 1984;93:101-13.
2
Gastrointestinal mucus gel rheology.胃肠道黏液凝胶流变学
Symp Soc Exp Biol. 1989;43:65-71.
3
Changes in the structure of the mucous gel on the mucosal surface of the stomach in association with peptic ulcer disease.与消化性溃疡疾病相关的胃黏膜表面黏液凝胶结构的变化。
Gastroenterology. 1982 May;82(5 Pt 1):827-31.
4
Mechanical characterization and properties of gastrointestinal mucus gel.胃肠道黏液凝胶的力学特性与性能
Biorheology. 1987;24(6):615-23. doi: 10.3233/bir-1987-24614.
5
Gastric mucus and mucosal injury.
Mater Med Pol. 1976 Apr-Jun;8(2):177-85.
6
Gastroduodenal defence mechanisms.胃十二指肠防御机制
Clin Gastroenterol. 1984 May;13(2):327-54.
7
Mucus glycoprotein structure, gel formation and gastrointestinal mucus function.黏液糖蛋白结构、凝胶形成与胃肠黏液功能
Ciba Found Symp. 1984;109:137-56. doi: 10.1002/9780470720905.ch10.
8
Helicobacter pylori infection and gastric secretion in duodenal and gastric ulcer patients--the effect of eradication after one year.十二指肠溃疡和胃溃疡患者的幽门螺杆菌感染及胃分泌情况——根除治疗一年后的效果
J Physiol Pharmacol. 1997 Sep;48(3):353-64.
9
[Sialic acid, a marker for peptic proteolysis of gastric mucus glycoproteins: physiopathological significance in man].
Gastroenterol Clin Biol. 1985;9(12 Pt 2):108-10.
10
Bile salts stimulate mucous glycoprotein secretion from cultured rabbit gastric mucosal cells.胆汁盐可刺激培养的兔胃黏膜细胞分泌黏液糖蛋白。
J Lab Clin Med. 1994 Sep;124(3):395-400.

引用本文的文献

1
Gastroprotective Efficacy of North African Medicinal Plants: A Review on Their Therapeutic Potential for Peptic Ulcers.北非药用植物的胃保护功效:关于其治疗消化性溃疡潜力的综述
Food Sci Nutr. 2024 Oct 22;12(11):8793-8824. doi: 10.1002/fsn3.4536. eCollection 2024 Nov.
2
Characterizing interregional differences in the rheological properties and composition of rat small intestinal mucus.表征大鼠小肠黏液流变学特性和组成的区域性差异。
Drug Deliv Transl Res. 2024 Nov;14(11):3309-3320. doi: 10.1007/s13346-024-01574-1. Epub 2024 Mar 25.
3
Underlying beneficial effects of Rhubarb on constipation-induced inflammation, disorder of gut microbiome and metabolism.
大黄对便秘诱导的炎症、肠道微生物群紊乱和代谢的潜在有益作用。
Front Pharmacol. 2022 Dec 5;13:1048134. doi: 10.3389/fphar.2022.1048134. eCollection 2022.
4
Development of a Genome-Scale Metabolic Model and Phenome Analysis of the Probiotic Strain Nissle 1917.开发全基因组代谢模型和益生菌菌株 1917 表型分析。
Int J Mol Sci. 2021 Feb 20;22(4):2122. doi: 10.3390/ijms22042122.
5
The Role of Glycans in Bacterial Adhesion to Mucosal Surfaces: How Can Single-Molecule Techniques Advance Our Understanding?聚糖在细菌黏附于黏膜表面中的作用:单分子技术如何推动我们的理解?
Microorganisms. 2018 May 4;6(2):39. doi: 10.3390/microorganisms6020039.
6
Micro- and macrorheology of mucus.黏液的微观和宏观流变学
Adv Drug Deliv Rev. 2009 Feb 27;61(2):86-100. doi: 10.1016/j.addr.2008.09.012. Epub 2009 Jan 3.
7
Past, present, and future technologies for oral delivery of therapeutic proteins.用于治疗性蛋白质口服递送的过去、现在和未来技术。
J Pharm Sci. 2008 Jul;97(7):2497-523. doi: 10.1002/jps.21183.
8
Protective effects of Ginkgo biloba extract on the ethanol-induced gastric ulcer in rats.银杏叶提取物对大鼠乙醇诱导型胃溃疡的保护作用。
World J Gastroenterol. 2005 Jun 28;11(24):3746-50. doi: 10.3748/wjg.v11.i24.3746.
9
Susceptibility of the cysteine-rich N-terminal and C-terminal ends of rat intestinal mucin muc 2 to proteolytic cleavage.大鼠肠道黏蛋白MUC2富含半胱氨酸的N末端和C末端对蛋白水解切割的敏感性。
Biochem J. 1998 Apr 1;331 ( Pt 1)(Pt 1):323-30. doi: 10.1042/bj3310323.
10
Secretory immunoglobulin A, intestinal mucin, and mucosal permeability in nutritionally induced bacterial translocation in rats.分泌型免疫球蛋白A、肠道粘蛋白与大鼠营养诱导性细菌移位中的黏膜通透性
Ann Surg. 1994 Dec;220(6):798-808. doi: 10.1097/00000658-199412000-00014.