利血平加氢氯噻嗪以及索他洛尔加氢氯噻嗪用于黑人和印度裔高血压患者。

Reserpine plus hydrochlorothiazide and sotalol plus hydrochlorothiazide in Black and Indian hypertensive patients.

作者信息

Seedat Y K, Hoosen S, Bhigjee A I

出版信息

S Afr Med J. 1984 Jun 9;65(23):915-7.

Abstract

Fifty patients (25 Blacks and 25 Indians) suffering from mild-to-moderate hypertension (supine diastolic blood pressure 100 - 105 mmHg) were studied in order to compare the antihypertensive effect of a combination of a beta-blocker (sotalol hydrochloride 160 mg/d) plus a thiazide derivative (hydrochlorothiazide 25 mg/d) ( Sotazide ; B-M) with that of a combination of reserpine 0,1 mg/d ( Serpasil ; Ciba) plus hydrochlorothiazide 25 mg/d ( Dichlotride ; Frosst MSD). The combination of reserpine plus hydrochlorothiazide was found to be as effective as that of sotalol plus hydrochlorothiazide in lowering the blood pressure in both the Black and the Indian patients. Two patients taking the combination containing reserpine developed side-effects, but this did not occur in any of those taking the combination containing sotalol. We feel that in developing countries, where the cost of therapy is important, reserpine in a dosage of less than 0,1 mg/d plus a thiazide derivative in low dosage is preferable to a beta-blocker plus a thiazide derivative in the treatment of hypertension.

摘要

对50名患有轻度至中度高血压（仰卧位舒张压为100 - 105 mmHg）的患者（25名黑人患者和25名印度患者）进行了研究，以比较β受体阻滞剂（盐酸索他洛尔160 mg/d）加噻嗪类衍生物（氢氯噻嗪25 mg/d）（索他噻嗪；B - M）与利血平0.1 mg/d（利血平；西巴）加氢氯噻嗪25 mg/d（双氯噻嗪；弗罗斯特默克）联合用药的降压效果。结果发现，在黑人和印度患者中，利血平加氢氯噻嗪联合用药在降低血压方面与索他洛尔加氢氯噻嗪联合用药效果相当。两名服用含利血平联合用药的患者出现了副作用，但服用含索他洛尔联合用药的患者均未出现这种情况。我们认为，在治疗费用很重要的发展中国家，在高血压治疗中，剂量小于0.1 mg/d的利血平加低剂量噻嗪类衍生物比β受体阻滞剂加噻嗪类衍生物更可取。