Kay P H, Dawkins R L
Tissue Antigens. 1984 Mar;23(3):151-5. doi: 10.1111/j.1399-0039.1984.tb00025.x.
Plasma samples from 129 dogs have been typed using an immunofixation technique to define the polymorphism of canine C4. The mode of inheritance was inferred by study of four large pedigrees. In contrast to the situation in man, canine C4 may be encoded by a single locus. At least five different co-dominant structural alleles have been detected. A deficiency allele has not been found as yet. Because there are associations between C4 allotypes and spontaneous autoimmune disease in man, the well defined polymorphism of canine C4 may provide an excellent model for understanding of the pathogenetic mechanisms of autoimmune disease.
利用免疫固定技术对129只犬的血浆样本进行分型，以确定犬C4的多态性。通过对四个大型家系的研究推断出遗传模式。与人类的情况不同，犬C4可能由单个基因座编码。已检测到至少五种不同的共显性结构等位基因。目前尚未发现缺陷等位基因。由于人类中C4同种异型与自发性自身免疫性疾病之间存在关联，犬C4明确的多态性可能为理解自身免疫性疾病的发病机制提供一个极好的模型。
