Zaslavskaia P L, Teteriatnik A F, Zhukov V G, Dzegilenko N B
Antibiotiki. 1978 Mar;23(3):208-11.
Four mutants of Proactinomyces (Nocardia) mediterranei, an organism producing rifamycin B were subjected to electron microscopic investigation. The mutants differed in the biosynthetic activity. The investigation showed correlation between the length of the hyphal fragments of the over-substrate mycelium and the level of the organism activity. The study of the fine structure of the mycelium revealed changes in the structure of the cell wall, character of the nuclear material and hyphae vacuolization.
对产利福霉素B的地中海原放线菌（诺卡氏菌）的四个突变体进行了电子显微镜研究。这些突变体在生物合成活性方面存在差异。研究表明，底物上菌丝体的菌丝片段长度与生物体活性水平之间存在相关性。对菌丝体精细结构的研究揭示了细胞壁结构、核物质特征和菌丝空泡化的变化。
