Sanchez S, Demain A L
Appl Environ Microbiol. 1978 Feb;35(2):459-61. doi: 10.1128/aem.35.2.459-461.1978.
The growth of a bradytrophic mutant isolated from the methanol-utilizing yeast Hansenula polymorpha was found to be stimulated by both tyrosine and phenylalanine. The mutant contained about half as much chorismate mutase activity as the wild-type strain. When grown in a medium containing 2% mehtanol as the major carbon and energy source, the bradytroph excreted a low but significant level (28 mg/liter) of L-tryptophan.
从多形汉逊酵母这种利用甲醇的酵母中分离出的一种生长缓慢的突变体，其生长受到酪氨酸和苯丙氨酸的刺激。该突变体所含分支酸变位酶活性约为野生型菌株的一半。当在以2%甲醇作为主要碳源和能源的培养基中生长时，这种生长缓慢的突变体分泌出低水平但显著量（28毫克/升）的L-色氨酸。
