Morcillo E J, Perpiñá M, Esplugues J
Am Rev Respir Dis. 1984 Jun;129(6):948-51. doi: 10.1164/arrd.1984.129.6.948.
The responsiveness of lung parenchymal strips isolated from actively sensitized guinea pigs to some selected autacoids (histamine, 5-hydroxytryptamine, bradykinin, and prostaglandins F2 alpha and l2) and autonomic drugs (acetylcholine, norepinephrine, methoxamine, and isoprenaline) was compared with that of strips from unsensitized animals. The concentration-response curves to the agonists, with the only exception of isoprenaline, in the sensitized group exhibited a left upward displacement (greater maximal effects and less effective concentration 50%) compared with those obtained in the unsensitized group. These results indicate the existence of a nonspecific increase in responsiveness of lung parenchymal strip isolated from sensitized animals.
将从主动致敏豚鼠分离出的肺实质条对某些选定的自体活性物质（组胺、5-羟色胺、缓激肽、前列腺素F2α和I2）和自主神经药物（乙酰胆碱、去甲肾上腺素、甲氧明和异丙肾上腺素）的反应性与未致敏动物的肺实质条进行了比较。与未致敏组相比，致敏组中除异丙肾上腺素外，对激动剂的浓度-反应曲线均表现出向左上移位（最大效应更大，有效浓度50%更低）。这些结果表明，从致敏动物分离出的肺实质条存在非特异性反应性增加。
