Parsegian V A, Rand R P
Ann N Y Acad Sci. 1983;416:1-12. doi: 10.1111/j.1749-6632.1983.tb35175.x.
Membrane interaction and membrane deformation should be considered two aspects of the same phenomenon. Because membrane interaction depends on structural features such as curvature, chemical composition, and surface organization, one must expect that these features will change as membranes are brought together. Our observations on model phospholipid membranes have allowed us to measure and to distinguish electrostatic (coulombic or double-layer) forces, electrodynamic (van der Waals, dispersion) interactions, and hydration forces due to the solvation of polar groups that are stabilizing the membrane surface. As a consequence of these interactions, approaching membranes may flatten against each other, may change the packing density of their constituent molecules, may rearrange the composition of components in regions close to the apposing membrane, or may even show conformational changes in the arrangement of the lipid hydrocarbon chains. Abundant examples of such deformation accompanying membrane interaction are evident from x-ray diffraction and electron microscopic observations.
膜相互作用和膜变形应被视为同一现象的两个方面。由于膜相互作用取决于诸如曲率、化学成分和表面组织等结构特征，所以人们必定会预期，当膜相互靠近时，这些特征将会发生变化。我们对模型磷脂膜的观察使我们能够测量并区分静电（库仑力或双层）力、电动（范德华力、色散力）相互作用以及由于稳定膜表面的极性基团溶剂化而产生的水化力。这些相互作用的结果是，相互靠近的膜可能会彼此贴合变平，可能会改变其组成分子的堆积密度，可能会重新排列靠近对置膜区域内的成分组成，甚至可能会在脂质烃链的排列上表现出构象变化。从X射线衍射和电子显微镜观察中可以明显看出许多伴随膜相互作用而发生这种变形的例子。
