Parsegian V A, Rau D C
J Cell Biol. 1984 Jul;99(1 Pt 2):196s-200s. doi: 10.1083/jcb.99.1.196s.
In this paper we make the following points: Water is perturbed within several angstroms of the surfaces of soluble molecules. Removal of this water can require significant amounts of work, seen as an exponentially varying "hydration force" with respect to molecular separation. The favorable and specific attractions that occur in molecular assembly or in ligand binding imply that the specific association between the molecular surfaces is stronger than the association of those surfaces with water. The specificity of biochemical association is not simply a matter of protein-protein interaction but also of competing protein-water interactions. Small structural changes in molecular surfaces can evoke large changes in the contact energy of hydrated surfaces; surface hydration and the energetics of water displacement are a likely mechanism for the contact specificity of intracellular associations integrating the cell matrix.
在本文中，我们提出以下观点：水在可溶性分子表面的几个埃范围内受到扰动。去除这些水可能需要大量的功，这表现为相对于分子间距呈指数变化的“水化力”。分子组装或配体结合中发生的有利且特异的吸引力意味着分子表面之间的特异性结合强于这些表面与水的结合。生化结合的特异性不仅是蛋白质 - 蛋白质相互作用的问题，也是蛋白质 - 水相互作用竞争的问题。分子表面的微小结构变化可引起水合表面接触能的巨大变化；表面水合作用和水置换的能量学可能是整合细胞基质的细胞内结合接触特异性的一种机制。
