移植性大鼠嗜铬细胞瘤中儿茶酚胺及其代谢产物的排泄

Excretion of catecholamines and their metabolites in transplantable rat phaeochromocytoma.

作者信息

Rein G, Ruthven C R, Goodwin B L, Perlman R L, Sandler M

出版信息

Biochem Pharmacol. 1984 May 1;33(9):1411-5. doi: 10.1016/0006-2952(84)90406-4.

Abstract

The urinary excretion pattern of catecholamines and their metabolites was studied in rats bearing a subcutaneous transplantable phaeochromocytoma. Compared with normal rats, tumour-bearing animals showed a markedly raised excretion of dopamine, noradrenaline and adrenaline, together with certain of their major acidic and alcoholic metabolites. No evidence of increased octopamine production could be obtained. There was a significant correlation between the output of dopamine and its metabolites, allowing accurate assessment of dopamine turnover rates which were comparable with those observed in human phaeochromocytoma. Tumour development, as determined by tumour weight, also correlated significantly with urinary excretion of noradrenaline and dopamine. Rat phaeochromocytoma appears to be a useful model for the human tumour.

摘要

对携带皮下可移植嗜铬细胞瘤的大鼠的儿茶酚胺及其代谢产物的尿排泄模式进行了研究。与正常大鼠相比，荷瘤动物的多巴胺、去甲肾上腺素和肾上腺素及其某些主要酸性和醇性代谢产物的排泄量明显升高。未获得章鱼胺产量增加的证据。多巴胺及其代谢产物的产量之间存在显著相关性，从而能够准确评估多巴胺周转率，该周转率与在人类嗜铬细胞瘤中观察到的周转率相当。由肿瘤重量确定的肿瘤发展也与去甲肾上腺素和多巴胺的尿排泄量显著相关。大鼠嗜铬细胞瘤似乎是人类肿瘤的一个有用模型。