Airoldi M, Negri L, Pedani F, Gerbino G, Gandolfo S, Patriarca E
Boll Soc Ital Biol Sper. 1984 Apr 30;60(4):871-5.
Using an immunoperoxidase method the Authors have demonstrated carcinoembryonic antigen (CEA) in 4/7 patients with benign oral lesion and in 9/10 patients with oral cancer. All 4 oral leukoplakias were positive for CEA. The histologic presence of CEA in oral cancer was related mainly to the formation of well differentiated tissue. The anaplastic carcinoma was negative. These findings indicate that CEA is a product of differentiated cells and should not be considered exclusively an oncofetal antigen or a marker of undifferentiated cells.
作者采用免疫过氧化物酶法，在7例良性口腔病变患者中的4例以及10例口腔癌患者中的9例检测到癌胚抗原（CEA）。所有4例口腔白斑病患者的CEA均呈阳性。口腔癌中CEA的组织学存在主要与高分化组织的形成有关。间变性癌呈阴性。这些发现表明，CEA是分化细胞的产物，不应仅被视为一种癌胚抗原或未分化细胞的标志物。
