右美沙芬和青藤碱作为镇咳药的客观评价。
Objective evaluation of dextromethorphan and glaucine as antitussive agents.
作者信息
Rühle K H, Criscuolo D, Dieterich H A, Köhler D, Riedel G
出版信息
Br J Clin Pharmacol. 1984 May;17(5):521-4. doi: 10.1111/j.1365-2125.1984.tb02384.x.
Abstract
Twenty-four inpatients affected by chronic cough completed a single-dose double-blind cross-over study of placebo, glaucine 30 mg and dextromethorphan 30 mg. The study was carried out using a balanced incomplete block design, each patient receiving two of the three experimental treatments. Objective evaluation of cough was ensured by means of a writing cough recorder. Coughs after dextromethorphan and glaucine were fewer than coughs after placebo: however only glaucine was significantly different from placebo in reducing coughs. Treatments were well tolerated: clinical results included a reduction in pulse rate after both dextromethorphan and glaucine , and a large number of patients reporting side effects after dextromethorphan administration.
摘要
24名慢性咳嗽住院患者完成了一项关于安慰剂、30毫克海葱素和30毫克右美沙芬的单剂量双盲交叉研究。该研究采用平衡不完全区组设计进行，每位患者接受三种实验治疗中的两种。通过书写式咳嗽记录仪确保对咳嗽进行客观评估。右美沙芬和海葱素后的咳嗽次数少于安慰剂后的咳嗽次数：然而，只有海葱素在减少咳嗽方面与安慰剂有显著差异。治疗耐受性良好：临床结果包括右美沙芬和海葱素后脉搏率降低，以及大量患者在服用右美沙芬后报告有副作用。
相似文献
1
Objective evaluation of dextromethorphan and glaucine as antitussive agents.右美沙芬和青藤碱作为镇咳药的客观评价。
Br J Clin Pharmacol. 1984 May;17(5):521-4. doi: 10.1111/j.1365-2125.1984.tb02384.x.
2
Double-blind study of glaucine in chronic cough.海罂粟碱治疗慢性咳嗽的双盲研究。
Int J Clin Pharmacol Ther Toxicol. 1981 Sep;19(9):396-9.
3
Efficacy and tolerability of glaucine as an antitussive agent.青藤碱作为镇咳药的疗效和耐受性。
Curr Med Res Opin. 1984;9(1):21-7. doi: 10.1185/03007998409109554.
4
Dextromethorphan and codeine: objective assessment of antitussive activity in patients with chronic cough.右美沙芬和可待因：慢性咳嗽患者镇咳活性的客观评估
J Int Med Res. 1983;11(2):92-100. doi: 10.1177/030006058301100206.
5
Antitussive effect of dextromethorphan and dextromethorphan-salbutamol combination in healthy volunteers with artificially induced cough.
Respiration. 1987;52(1):49-53. doi: 10.1159/000195303.
6
7
The antitussive effect of dextromethorphan in relation to CYP2D6 activity.右美沙芬的镇咳作用与细胞色素P450 2D6（CYP2D6）活性的关系。
Br J Clin Pharmacol. 1999 Sep;48(3):382-7. doi: 10.1046/j.1365-2125.1999.00029.x.
8
Assessment of antitussive efficacy of dextromethorphan in smoking related cough: objective vs. subjective measures.右美沙芬对吸烟相关性咳嗽的镇咳疗效评估：客观指标与主观指标对比
Br J Clin Pharmacol. 2008 May;65(5):737-41. doi: 10.1111/j.1365-2125.2008.03115.x. Epub 2008 Feb 15.
9
Efficacy and tolerability of levodropropizine in adult patients with non-productive cough. Comparison with dextromethorphan.左羟丙哌嗪在无痰干咳成年患者中的疗效及耐受性。与右美沙芬的比较。
Pulm Pharmacol Ther. 1997;10(2):89-96. doi: 10.1006/pupt.1997.0083.
10
Objective and self-reported evidence of dextromethorphan antitussive efficacy in children, aged 6-11 years, with acute cough due to the common cold.目的和自我报告的右美沙芬镇咳疗效的证据在儿童，年龄 6-11 岁，与急性咳嗽由于普通感冒。
Pediatr Pulmonol. 2023 Aug;58(8):2229-2239. doi: 10.1002/ppul.26416. Epub 2023 May 26.
引用本文的文献
1
Glaucine inhibits breast cancer cell migration and invasion by inhibiting MMP-9 gene expression through the suppression of NF-κB activation.青藤碱通过抑制NF-κB激活来抑制MMP-9基因表达，从而抑制乳腺癌细胞的迁移和侵袭。
Mol Cell Biochem. 2015 May;403(1-2):85-94. doi: 10.1007/s11010-015-2339-9. Epub 2015 Feb 11.
2
Antitussive drugs--past, present, and future.镇咳药——过去、现在与未来。
Pharmacol Rev. 2014 Mar 26;66(2):468-512. doi: 10.1124/pr.111.005116. Print 2014.
3
Antitussive effects of memantine in guinea pigs.美金刚对豚鼠的镇咳作用。
Chest. 2012 Apr;141(4):996-1002. doi: 10.1378/chest.11-0554. Epub 2011 Oct 20.
4
Peripheral mechanisms II: the pharmacology of peripherally active antitussive drugs.外周机制II：外周活性镇咳药的药理学
Handb Exp Pharmacol. 2009;187(187):155-86. doi: 10.1007/978-3-540-79842-2_8.
5
Assessment of antitussive efficacy of dextromethorphan in smoking related cough: objective vs. subjective measures.右美沙芬对吸烟相关性咳嗽的镇咳疗效评估：客观指标与主观指标对比
Br J Clin Pharmacol. 2008 May;65(5):737-41. doi: 10.1111/j.1365-2125.2008.03115.x. Epub 2008 Feb 15.
6
Appropriate use of antitussives and protussives. A practical review.镇咳药与祛痰药的合理使用。实用综述。
Drugs. 1993 Jul;46(1):80-91. doi: 10.2165/00003495-199346010-00006.
7
Night cough and general practice research.夜间咳嗽与全科医学研究。
J R Coll Gen Pract. 1986 Feb;36(283):74-7.
本文引用的文献
1
OBJECTIVE ASSESSMENT OF COUGH SUPPRESSANTS UNDER CLINICAL CONDITIONS USING A TAPE RECORDER SYSTEM.使用录音机系统在临床条件下对止咳药进行客观评估。
Thorax. 1964 Mar;19(2):125-30. doi: 10.1136/thx.19.2.125.
2
[Evaluation of cough-suppressing substances in humans].[人体中镇咳物质的评估]
Arzneimittelforschung. 1955 Jul;5(7):364-7.
3
Experimental studies of the abuse potential of d, l-glaucine. 1.5-phosphate in rhesus monkeys.恒河猴中d，l-青藤碱1.5-磷酸盐滥用潜力的实验研究。
Pharmacol Biochem Behav. 1982 May;16(5):851-4. doi: 10.1016/0091-3057(82)90248-9.
4
Double-blind study of glaucine in chronic cough.海罂粟碱治疗慢性咳嗽的双盲研究。
Int J Clin Pharmacol Ther Toxicol. 1981 Sep;19(9):396-9.
5
Double-blind comparison of the respiratory and sedative effects of codeine phosphate and (+/-)-glaucine phosphate in human volunteers.磷酸可待因和磷酸（±）-青藤碱对人体志愿者呼吸及镇静作用的双盲比较
Br J Clin Pharmacol. 1982 Oct;14(4):555-8. doi: 10.1111/j.1365-2125.1982.tb02028.x.
6
[Action of Tussiglaucin--a new antitussive and anti-asthmatic agent].[新型镇咳平喘药吐昔咯辛的作用]
Pol Tyg Lek. 1972 Dec 25;27(52):2071-3.
7
[Comparison of the antitussive effect of two different drugs regarding frequency and strength of cough attacks (author's transl)].
Med Klin. 1977 Nov 25;72(47):2019-23.
8
Circadian variation of blood-pressure.血压的昼夜变化
Lancet. 1978 Apr 15;1(8068):795-7. doi: 10.1016/s0140-6736(78)92998-7.
Zotero 插件