右美沙芬和青藤碱作为镇咳药的客观评价。
Objective evaluation of dextromethorphan and glaucine as antitussive agents.
作者信息
Rühle K H, Criscuolo D, Dieterich H A, Köhler D, Riedel G
出版信息
Br J Clin Pharmacol. 1984 May;17(5):521-4. doi: 10.1111/j.1365-2125.1984.tb02384.x.
Abstract
Twenty-four inpatients affected by chronic cough completed a single-dose double-blind cross-over study of placebo, glaucine 30 mg and dextromethorphan 30 mg. The study was carried out using a balanced incomplete block design, each patient receiving two of the three experimental treatments. Objective evaluation of cough was ensured by means of a writing cough recorder. Coughs after dextromethorphan and glaucine were fewer than coughs after placebo: however only glaucine was significantly different from placebo in reducing coughs. Treatments were well tolerated: clinical results included a reduction in pulse rate after both dextromethorphan and glaucine , and a large number of patients reporting side effects after dextromethorphan administration.
摘要
24名慢性咳嗽住院患者完成了一项关于安慰剂、30毫克海葱素和30毫克右美沙芬的单剂量双盲交叉研究。该研究采用平衡不完全区组设计进行，每位患者接受三种实验治疗中的两种。通过书写式咳嗽记录仪确保对咳嗽进行客观评估。右美沙芬和海葱素后的咳嗽次数少于安慰剂后的咳嗽次数：然而，只有海葱素在减少咳嗽方面与安慰剂有显著差异。治疗耐受性良好：临床结果包括右美沙芬和海葱素后脉搏率降低，以及大量患者在服用右美沙芬后报告有副作用。
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本文引用的文献
1
OBJECTIVE ASSESSMENT OF COUGH SUPPRESSANTS UNDER CLINICAL CONDITIONS USING A TAPE RECORDER SYSTEM.使用录音机系统在临床条件下对止咳药进行客观评估。
Thorax. 1964 Mar;19(2):125-30. doi: 10.1136/thx.19.2.125.
2
[Evaluation of cough-suppressing substances in humans].
Arzneimittelforschung. 1955 Jul;5(7):364-7.
3
Experimental studies of the abuse potential of d, l-glaucine. 1.5-phosphate in rhesus monkeys.恒河猴中d，l-青藤碱1.5-磷酸盐滥用潜力的实验研究。
Pharmacol Biochem Behav. 1982 May;16(5):851-4. doi: 10.1016/0091-3057(82)90248-9.
4
Double-blind study of glaucine in chronic cough.海罂粟碱治疗慢性咳嗽的双盲研究。
Int J Clin Pharmacol Ther Toxicol. 1981 Sep;19(9):396-9.
5
Double-blind comparison of the respiratory and sedative effects of codeine phosphate and (+/-)-glaucine phosphate in human volunteers.磷酸可待因和磷酸（±）-青藤碱对人体志愿者呼吸及镇静作用的双盲比较
Br J Clin Pharmacol. 1982 Oct;14(4):555-8. doi: 10.1111/j.1365-2125.1982.tb02028.x.
6
[Action of Tussiglaucin--a new antitussive and anti-asthmatic agent].[新型镇咳平喘药吐昔咯辛的作用]
Pol Tyg Lek. 1972 Dec 25;27(52):2071-3.
7
[Comparison of the antitussive effect of two different drugs regarding frequency and strength of cough attacks (author's transl)].
Med Klin. 1977 Nov 25;72(47):2019-23.
8
Circadian variation of blood-pressure.血压的昼夜变化
Lancet. 1978 Apr 15;1(8068):795-7. doi: 10.1016/s0140-6736(78)92998-7.
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