Dierckx P, Leblanc G, Decoster A, Criscuolo D
Int J Clin Pharmacol Ther Toxicol. 1981 Sep;19(9):396-9.
Thirty-eight patients, affected by chronic cough and hospitalized in 14 different rooms, entered a double-blind cross-over trial aimed at evaluating efficacy and tolerance of single oral doses of glaucine (eo mg) versus single oral doses of codeine (30 mg) and placebo. Patients occupying the same room were administered on 3 consecutive nights, and an objective evaluation of efficacy was ensured by means of a tape recorded. The mean cough counts during the 8-h interval after drug administration were 269.3 after placebo, 241.8 after glaucine, and 201.9 after codeine (p less than 0.05). The antitussive effects of glaucine and codeine were practically superimposable up to the 6th h, when glaucine effect declined. Treatments were well tolerated by all the patients, they themselves were not able to detect any difference in cough suppression among the three treatments.
38名患有慢性咳嗽且被安排在14个不同病房住院的患者，进入了一项双盲交叉试验，旨在评估单次口服格劳辛（60毫克）与单次口服可待因（30毫克）及安慰剂的疗效和耐受性。住在同一病房的患者连续三个晚上接受给药，并通过录音确保对疗效进行客观评估。给药后8小时内的平均咳嗽次数，服用安慰剂后为269.3次，服用格劳辛后为241.8次，服用可待因后为201.9次（p小于0.05）。在第6小时之前，格劳辛和可待因的镇咳效果几乎是叠加的，之后格劳辛的效果下降。所有患者对治疗的耐受性良好，他们自己无法察觉到三种治疗在咳嗽抑制方面有任何差异。
