Kristensen S D, Knudsen F, Nielsen A H, Ring T
Clin Nephrol. 1984 Apr;21(4):230-4.
Evidence is accumulating that activation of platelets occurs during conventional hemodialysis. In ten uremic patients, the ADP-induced platelet aggregation and the platelet sensitivity to prostacyclin (PGI2) were examined before and after 120 and 240 minutes of dialysis. The ADP-induced aggregation was enhanced during dialysis reaching statistical significance after 240 minutes compared to predialysis values. The platelet sensitivity to PGI2 was significantly diminished during dialysis. Our results are in agreement with the concept of platelet activation during hemodialysis and lend support to the clinical use of PGI2 during hemodialysis.
越来越多的证据表明，在常规血液透析过程中会发生血小板激活。在10名尿毒症患者中，检测了透析120分钟和240分钟前后二磷酸腺苷（ADP）诱导的血小板聚集以及血小板对前列环素（PGI2）的敏感性。透析过程中ADP诱导的聚集增强，与透析前值相比，240分钟后达到统计学意义。透析过程中血小板对PGI2的敏感性显著降低。我们的结果与血液透析过程中血小板激活的概念一致，并支持在血液透析过程中临床使用PGI2。
