Rhodes G R, Syracuse D C, McIntosh C L
Ann Thorac Surg. 1978 Apr;25(4):329-35. doi: 10.1016/s0003-4975(10)63550-3.
The effects of selective coronary vein occlusion (SCVO) and selective retrograde arterialization of the coronary vein (SRACV) on nutritional myocardial blood flow was evaluated in 10 dogs with radioactive microspheres. SRACV was performed with a shunt interposed between the aorta and the great cardiac vein (GCV). Following ligation of the GCV, measurements were performed before and after ligation of the middle portion of the left anterior descending coronary artery (LAD) and then after 15 and 30 minutes of SRACV. The myocardium was divided into three regions: circumflex coronary artery (served as control), high LAD (proximal to arterial occlusion; supplied by both SRACV and coronary flow), and low LAD (distal to arterial occlusion; supplied by SRACV alone). SCVO decreased mean myocardial blood flow with increased distribution to the endocardium. SRACV to normally perfused myocardium did not significantly change myocardial blood flow; however, SRACV to acutely ischemic myocardium restored less than 50% of the decrease in myocardial blood flow. SRACV does not appear to greatly enhance blood flow to ischemic areas of the myocardium and may significantly reduce flow on the basis of venous occlusion alone.
在10只犬中，采用放射性微球评估选择性冠状静脉闭塞（SCVO）和冠状静脉选择性逆行动脉化（SRACV）对心肌营养性血流的影响。通过在主动脉和冠状大静脉（GCV）之间插入分流装置进行SRACV。结扎GCV后，在结扎左前降支冠状动脉（LAD）中段之前和之后以及SRACV 15分钟和30分钟后进行测量。心肌分为三个区域：回旋支冠状动脉（作为对照）、高LAD（动脉闭塞近端；由SRACV和冠状动脉血流共同供血）和低LAD（动脉闭塞远端；仅由SRACV供血）。SCVO使平均心肌血流减少，且心内膜分布增加。对正常灌注心肌进行SRACV不会显著改变心肌血流；然而，对急性缺血心肌进行SRACV只能恢复不到50%的心肌血流减少量。SRACV似乎不会显著增加心肌缺血区域的血流，且仅基于静脉闭塞就可能显著减少血流。
