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Effect of diltiazem on plasma glucose, insulin and glucagon during an oral glucose tolerance test in healthy volunteers.

作者信息

Segrestaa J M, Caulin C, Dahan R, Houlbert D, Thiercelin J F, Herman P, Sauvanet J P, Larribaud J

出版信息

Eur J Clin Pharmacol. 1984;26(4):481-3. doi: 10.1007/BF00542145.

DOI:10.1007/BF00542145
PMID:6376146
Abstract

The effect of the calcium antagonist, diltiazem, on glycoregulation was investigated in 12 healthy volunteers using a standard glucose tolerance test. No significant change was observed in plasma glucose, insulin or glucagon levels after oral treatment for B days with diltiazem 180 mg/day.

摘要

相似文献

1
Effect of diltiazem on plasma glucose, insulin and glucagon during an oral glucose tolerance test in healthy volunteers.
Eur J Clin Pharmacol. 1984;26(4):481-3. doi: 10.1007/BF00542145.
2
Effect of diltiazem on insulin secretion. II. Experiments on perfused rat pancreas, anesthetized dogs and conscious rats.地尔硫䓬对胰岛素分泌的影响。II. 对灌注大鼠胰腺、麻醉犬及清醒大鼠的实验
Jpn J Pharmacol. 1979 Jun;29(3):375-83. doi: 10.1254/jjp.29.375.
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The pharmacokinetics and pharmacology of oral diltiazem in normal volunteers.
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引用本文的文献

1
Diltiazem. A review of its pharmacological properties and therapeutic efficacy.地尔硫䓬。其药理特性与治疗效果综述。
Drugs. 1985 May;29(5):387-454. doi: 10.2165/00003495-198529050-00001.
2
Effect of bepridil on metabolic control and insulin secretion in diabetics.苄普地尔对糖尿病患者代谢控制及胰岛素分泌的影响。
Eur J Clin Pharmacol. 1988;34(3):221-6. doi: 10.1007/BF00540947.
3
Lack of effect of nicardipine and diltiazem on glucose- and arginine-induced insulin release in obese subjects.尼卡地平和地尔硫䓬对肥胖受试者葡萄糖和精氨酸诱导的胰岛素释放无影响。

本文引用的文献

1
Effect of nifedipine on blood sugar, insulin and glucagon levels after an oral glucose load.
Panminerva Med. 1981 Apr-Jun;23(2):75-80.
2
Improvement of glucose tolerance by verapamil in patients with non-insulin-dependent diabetes mellitus.维拉帕米对非胰岛素依赖型糖尿病患者葡萄糖耐量的改善作用。
Acta Med Scand. 1981;210(1-2):27-33. doi: 10.1111/j.0954-6820.1981.tb09771.x.
3
Impairment of insulin secretion in man by nifedipine.
Eur J Clin Pharmacol. 1980 Nov;18(5):395-8. doi: 10.1007/BF00636791.
4
Cardiovasc Drugs Ther. 1988 Dec;2(5):669-72. doi: 10.1007/BF00054207.
Effect of nifedipine on glucose tolerance and insulin secretion in diabetic and non-diabetic patients.硝苯地平对糖尿病和非糖尿病患者糖耐量及胰岛素分泌的影响。
Curr Med Res Opin. 1980;6(10):690-3. doi: 10.1185/03007998009110082.
5
Hyperglycaemic effect of nifedipine.硝苯地平的高血糖效应。
Br Med J (Clin Res Ed). 1981 Jul 4;283(6283):19-20. doi: 10.1136/bmj.283.6283.19.
6
Coated charcoal immunoassay of insulin.胰岛素的包被炭免疫测定法。
J Clin Endocrinol Metab. 1965 Oct;25(10):1375-84. doi: 10.1210/jcem-25-10-1375.
7
Cobalt inhibition of insulin secretion and calcium uptake by isolated rat islets.钴对离体大鼠胰岛胰岛素分泌和钙摄取的抑制作用。
Am J Physiol. 1975 Jun;228(6):1669-77. doi: 10.1152/ajplegacy.1975.228.6.1669.
8
Calcium antagonists and islet function. I. Inhibition of insulin release by verapamil.钙拮抗剂与胰岛功能。I. 维拉帕米对胰岛素释放的抑制作用。
Diabetes. 1975 Jun;24(6):247-51. doi: 10.2337/diabetes.24.6.247.
9
Simple sensitive and specific gas chromatographic method for the quantification of diltiazem human body fluids.一种用于定量测定人体体液中地尔硫䓬的简单、灵敏且特异的气相色谱法。
J Chromatogr. 1977 Aug 11;138(2):391-8. doi: 10.1016/s0021-9673(00)94974-4.
10
Calcium antagonists and islet function. VIII. The effect of magnesium.钙拮抗剂与胰岛功能。VIII. 镁的作用。
Diabete Metab. 1976 Mar;2(1):1-4.