Georgiev V P, Dóda M, György L
Arch Int Pharmacodyn Ther. 1978 Jan;231(1):139-47.
The effects of intraventricularly (third, fourth and lateral cerebral ventricles) applied GABA and picrotoxin on blood pressure and reflexogenic hypertension and nictitating membrane contractions after central sciatic nerve stimulation were studied in lightly anaesthetized cats. The interactions between both substances were also studied. It was shown that picrotoxin caused a strong elevation of blood pressure and a long lasting contraction of the nictitating membrane when infused into each part of the cerebral ventricular system. These effects of picrotoxin were antagonized by GABA. GABA inhibited the reflexogenic hypertension when given into the fourth ventricle and the reflexogenic nictitating membrane contractions given into the third and fourth ventricles. Picrotoxin antagonized the inhibitory effects of GABA on the reflexogenic nictitating membrane contractions. It is concluded that in the central regulation of some somato-vegetative reflexes the GABA-ergic transmitter system takes part.
在轻度麻醉的猫身上，研究了脑室内（第三、第四和侧脑室）注入γ-氨基丁酸（GABA）和印防己毒素对血压、反射性高血压以及刺激坐骨神经中枢后瞬膜收缩的影响。同时也研究了这两种物质之间的相互作用。结果表明，当将印防己毒素注入脑室系统的各个部位时，会导致血压显著升高以及瞬膜长时间收缩。GABA可拮抗印防己毒素的这些作用。当将GABA注入第四脑室时，可抑制反射性高血压；当注入第三和第四脑室时，可抑制反射性瞬膜收缩。印防己毒素可拮抗GABA对反射性瞬膜收缩的抑制作用。由此得出结论，在某些体-植物性反射的中枢调节中，γ-氨基丁酸能递质系统参与其中。
