Dechaux M, Gonzalez G, Broyer M
Arch Fr Pediatr. 1978 Jan;35(1):53-62.
The 24 hour clearance of endogenous creatinine was compared with that of inulin in 112 children aged between 15 months and 17 years. The children had a variety of kidney disorders with renal function than ranged from normal to terminal renal failure. When the inulin clearance was less than 10 ml/min/1.73 m2 it was on average 75% of the value of the creatinine clearance. Between 10 and 60 ml/min/1.73 m2 the relationship of the inulin clearance to that of creatinine was similar (77%) but above 60 ml/min/1.73 m2 the ratio of the inulin clearance to that of creatinine was 1.05 with a wide scatter. With increasing degrees of renal failure the plasma creatinine increased less in the children under 2 years old than in those over this age so it is poor index of glomerular function in infants. In renal failure the urinary excretion of creatinine in 24 hours was reduced. When the clearance was less than 10 ml/min/1.73 m2, the urinary creatinine excretion for children under the age of 2 was 58% of the normal for the age and for children over 2, it was 86% of the expected mean.
对112名年龄在15个月至17岁之间的儿童，比较了内生肌酐与菊粉的24小时清除率。这些儿童患有各种肾脏疾病，其肾功能从正常到终末期肾衰竭不等。当菊粉清除率低于10 ml/min/1.73 m²时，其平均值为肌酐清除率值的75%。在10至60 ml/min/1.73 m²之间，菊粉清除率与肌酐清除率的关系相似（77%），但在60 ml/min/1.73 m²以上，菊粉清除率与肌酐清除率的比值为1.05，离散度较大。随着肾衰竭程度的增加，2岁以下儿童的血浆肌酐升高幅度小于2岁以上儿童，因此它不是婴儿肾小球功能的良好指标。在肾衰竭时，24小时尿肌酐排泄减少。当清除率低于10 ml/min/1.73 m²时，2岁以下儿童的尿肌酐排泄量为该年龄正常排泄量的58%，2岁以上儿童为预期平均值的86%。
