Snyder A J, Levin M P, Cutright D E
J Periodontol. 1984 May;55(5):273-7. doi: 10.1902/jop.1984.55.5.273.
Initial pilot studies using tricalcium phosphate ceramic placed into human periodontal osseous defects demonstrated osseous repair. Therefore, further evaluation of this material was undertaken on 17 carefully selected patients with 1-wall, 2-wall, crestal and furcation defects using standardized preoperative and postoperative radiographs, clinical measurements and clinical photographs. Inverse bevel, full-thickness flaps were raised, the areas debrided, root surfaces planed with ultrasonic and hand instrumentation, osseous penetrations made with curet point and the flaps sutured after the defects were filled. Eighteen-month reentry surgical procedures were performed on 10 of the 17 patients, with a resultant average of 2.8 mm of new bone. Controls were not used in this study since a protocol describing a sham procedure with other than 3-wall osseous defects was not acceptable in 1973 to the Clinical Human Use Committee. Although the tricalcium phosphate ceramic material was not found to be totally predictable in this study, it may nevertheless become a useful graft material because of its potential for osseous repair in combination with its availability, host acceptability, ease of manipulation and storage advantages.
最初将磷酸三钙陶瓷植入人类牙周骨缺损的初步试点研究证明了骨修复效果。因此，对17例精心挑选的患有单壁、双壁、嵴顶和根分叉缺损的患者使用标准化的术前和术后X光片、临床测量和临床照片对这种材料进行了进一步评估。掀起反斜角全厚瓣，清创，用超声和手动器械平整根面，用刮匙尖端进行骨穿透，缺损填充后缝合瓣。对17例患者中的10例进行了18个月的再次手术，平均长出了2.8毫米的新骨。本研究未设对照组，因为在1973年，临床人体使用委员会不接受除三壁骨缺损外的假手术方案。尽管在本研究中未发现磷酸三钙陶瓷材料完全可预测，但由于其骨修复潜力、可用性、宿主可接受性、易于操作和储存优势，它仍可能成为一种有用的移植材料。
