Lenoir G, Halter D, Seligman R, Dreuz C
Arch Fr Pediatr. 1978 Feb;35(2):187-97.
The pharmacokinetics and pharmacological effect of intravenous furosemide (F) (2 mg/kg body weight) were studied in 12 children with the nephrotic syndrome with or without renal failure (R.F.). The concentration of F in blood and urine was determined by a new spectrophotometric method. In the nephrotic syndrome alone, the rate of renal excretion was increased (increased slope of the pharmacokinetic curve, decreased t 1/2), which may be due to a decrease in the fraction bound to plasma albumin. In children with the nephrotic syndrome and renal failure, the decrease in the renal excretion of F was related to the degree of renal failure. In normal children the mean F clearance is 296. In patients with N.S. alone the clearance is greatly increased (X = 377) and in N.S. with R.F. it is reduced (0.17-90). The possible mechanisms and therapeutic implications of the results are discussed.
对12名患有或未患有肾衰竭（R.F.）的肾病综合征患儿研究了静脉注射速尿（F）（2毫克/千克体重）的药代动力学和药理作用。采用一种新的分光光度法测定血液和尿液中的F浓度。仅患有肾病综合征时，肾脏排泄率增加（药代动力学曲线斜率增加，t 1/2降低），这可能是由于与血浆白蛋白结合的部分减少所致。患有肾病综合征和肾衰竭的儿童中，F的肾脏排泄减少与肾衰竭程度有关。正常儿童的平均F清除率为296。仅患有肾病综合征的患者清除率大幅增加（X = 377），而患有肾病综合征合并肾衰竭的患者清除率降低（0.17 - 90）。讨论了结果的可能机制和治疗意义。
