Fujita K, Sakata H, Murono K, Yoshioka H, Maruyama S, Sanae N, Takimoto M
Jpn J Antibiot. 1984 Mar;37(3):329-37.
Forty-two pediatric patients were treated with ceftazidime ( CAZ ) in the doses ranging from 45.6 to 120 mg/kg/day for 2 to 10 days, and the clinical efficacy and side effects were evaluated. Among the 37 children with bacterial infections including pneumonia, bronchitis, tonsillitis, croup, cervical lymphadenitis, abdominal abscess and urinary tract infections, the results were excellent in 22, good in 12, fair in 2, and poor in 1 patient with pneumonia. Out of the 42 patients, 5 cases showed eosinophilia, but no clinical sign such as rash, fever or diarrhea, attributable to CAZ was observed during the study. The serum concentrations of CAZ in 4 patients ranged from 60.8 to 71.0 micrograms/ml (mean 66.1 micrograms/ml) at 30 minutes and from 0.5 to 1.2 micrograms/ml (mean 0.8 micrograms/ml) at 8 hours after 20 mg/kg intravenous bolus injection of the antibiotic. The mean serum half-life was 1.42 hours (85 minutes). Patients with impairment of renal function were excluded from this study.
42例儿科患者接受了头孢他啶（CAZ）治疗，剂量为45.6至120mg/kg/天，疗程2至10天，并对临床疗效和副作用进行了评估。在37例患有细菌感染（包括肺炎、支气管炎、扁桃体炎、哮吼、颈部淋巴结炎、腹部脓肿和尿路感染）的儿童中，22例效果极佳，12例良好，2例尚可，1例肺炎患者效果较差。42例患者中，5例出现嗜酸性粒细胞增多，但在研究期间未观察到与CAZ相关的皮疹、发热或腹泻等临床症状。4例患者在静脉推注20mg/kg抗生素后30分钟时，CAZ血清浓度为60.8至71.0微克/毫升（平均66.1微克/毫升），8小时时为0.5至1.2微克/毫升（平均0.8微克/毫升）。血清平均半衰期为1.42小时（85分钟）。肾功能损害患者被排除在本研究之外。
