Kim B, Meguro H, Arimasu O, Mashiko J, Ohnari S, Tagaya M, Sakamoto M, Fujii R
Jpn J Antibiot. 1984 Mar;37(3):363-76.
Ceftazidime (CAZ) was evaluated for its safety and efficacy in 31 children. Of the 25 confirmed bacterial infections, 23 were cured by the CAZ therapy (efficacy rate, 92%). CAZ was assessed as effective in acute pharyngitis with vomiting (4), acute laryngitis (1), pneumonia (8), urinary tract infections (5), acute gastroenteritis (1), infection accompanying acute leukemia (septicemia suspected) (1), acute purulent meningitis (2) and abscess of the lateral cervical cyst (1). The main pathogens which responded to CAZ were H. influenzae, S. pyogenes, E. coli and P. aeruginosa. As adverse events, mild melena with prolonged prothrombin time (1) was found to be associated with the CAZ therapy. Half-life of the CAZ serum level was 0.97 +/- 0.10 hours, and urinary excretion was high. Penetration into the CSF in 2 cases of acute purulent meningitis was satisfactory. The data suggest that CAZ is a safe and effective injectable antibiotic when used in children with infections of CAZ-susceptible bacteria including P. aeruginosa.
对31名儿童评估了头孢他啶（CAZ）的安全性和疗效。在25例确诊的细菌感染中，23例通过CAZ治疗治愈（有效率92%）。CAZ被评估对伴有呕吐的急性咽炎（4例）、急性喉炎（1例）、肺炎（8例）、尿路感染（5例）、急性胃肠炎（1例）、急性白血病伴发感染（疑似败血症）（1例）、急性化脓性脑膜炎（2例）和颈部外侧囊肿脓肿（1例）有效。对CAZ有反应的主要病原体为流感嗜血杆菌、化脓性链球菌、大肠杆菌和铜绿假单胞菌。作为不良事件，发现1例出现轻度黑便且凝血酶原时间延长与CAZ治疗有关。CAZ血清水平的半衰期为0.97±0.10小时，尿排泄率高。2例急性化脓性脑膜炎患者脑脊液中的药物渗透情况良好。数据表明，当用于患有包括铜绿假单胞菌在内的CAZ敏感菌感染的儿童时，CAZ是一种安全有效的注射用抗生素。
