[Use of monopeak insulin preparations in patients with type-1 diabetes mellitus].

Clinical studies of domestic purified insulin agents were performed in 35 patients (26 males and 9 females, aged 20 to 40 years old) suffering from I type diabetes mellitus. Among these patients 4 were with a labile disease course and 2 with insulin resistance. The effectiveness of the drugs mentioned was evaluated according to the acquired diabetes mellitus compensation, concerning carbohydrate metabolism, the diurnal variations in insulin requirement and anti-insulin antibody titer and a changed diabetes mellitus course. The purified insulin agents were effective in I type diabetes mellitus patients. They did not differ from the ordinary domestic drugs (su-insulin) by their hypoglycemic activity. The terms of diabetes compensation became shorter, the lability was removed and insulin resistance was overcome in some patients, using these drugs. The decreased antiinsulin titer and diurnal insulin requirement were noted in the majority of the patients.