Kiley J, Zager P
Am J Kidney Dis. 1984 Jul;4(1):39-43. doi: 10.1016/s0272-6386(84)80024-4.
Two patients with systemic lupus erythematosus (SLE) and hyperkalemia were studied. The hyperkalemia was disproportionate to the degree of renal excretory impairment. The usual causes of hyperkalemia were excluded. Basal levels of plasma renin activity (PRA) and plasma aldosterone (PAC) were low. The responses of PRA and plasma aldosterone to the combined stimulus of ambulation and furosemide were blunted. Plasma levels of 18-hydroxycorticosterone (18-OH-B) were normal. The hyperkalemia in both patients could be attributed to hyporeninemic hypoaldosteronism (HH). In one patient, the hyperkalemia was corrected by the administration of fludrocortisone. In the second patient, treatment of lupus nephritis with azathioprine, prednisone, and plasmapheresis normalized both the serum creatinine and the serum potassium.
对两名患有系统性红斑狼疮（SLE）和高钾血症的患者进行了研究。高钾血症与肾脏排泄功能损害程度不成比例。排除了高钾血症的常见病因。血浆肾素活性（PRA）和血浆醛固酮（PAC）的基础水平较低。PRA和血浆醛固酮对步行和呋塞米联合刺激的反应减弱。18-羟皮质酮（18-OH-B）的血浆水平正常。两名患者的高钾血症均归因于低肾素性低醛固酮血症（HH）。在一名患者中，通过给予氟氢可的松纠正了高钾血症。在第二名患者中，用硫唑嘌呤、泼尼松和血浆置换治疗狼疮性肾炎使血清肌酐和血清钾均恢复正常。
