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[不同来源变形杆菌菌株的抗生素耐药性]

[Resistance to antibiotics of Proteus strains from various sources].

作者信息

Korneva E P, Baĭramova A S, Iakh'eva S A, Slutskiĭ V I, Danevich M V

出版信息

Antibiotiki. 1984 Apr;29(4):263-71.

PMID:6378079
Abstract

To show the distribution level of antibiotic resistant strains of Proteus and determine the identity of the strains of different origin, i.e. those isolated from humans, animals and environment, the sensitivity of 1084 strains of P. mirabilis and P. vulgaris to chloramphenicol, streptomycin, monomycin, ampicillin, kanamycin, gentamicin and rondomycin was studied with the method of serial dilutions in agar. 964 of them belonged to 28 O-antigen serogroups. Comparative analysis of the data showed that the strains resistant to the above antibiotics were present in all the Proteus groups studied. However, their frequency was different and depended on the antibiotic type and the serological group and origin of the strain. All the strains were resistant to chloramphenicol, while the number of the strains resistant to gentamicin was minimum and did not depend on their origin. The frequency of the rondomycin resistant strains among the isolates from the environment of the agricultural farms was significantly lower. The frequency of the strains resistant to kanamycin, streptomycin and monomycin was significantly higher among the isolates from humans. The difference in the Proteus strains of serogroups 03 and 041, as well as the other serogroups by the detection frequency and resistance to some antibiotics and the portion of the strains of the 4 resistant types or spectra was shown to be significant.

摘要

为了展示变形杆菌抗生素耐药菌株的分布水平,并确定不同来源(即从人类、动物和环境中分离出的菌株)的菌株特性,采用琼脂连续稀释法研究了1084株奇异变形杆菌和普通变形杆菌对氯霉素、链霉素、新霉素、氨苄青霉素、卡那霉素、庆大霉素和制霉菌素的敏感性。其中964株属于28个O抗原血清群。数据的比较分析表明,在所研究的所有变形杆菌组中均存在对上述抗生素耐药的菌株。然而,它们的频率不同,取决于抗生素类型、菌株的血清学组和来源。所有菌株均对氯霉素耐药,而对庆大霉素耐药的菌株数量最少,且与它们的来源无关。来自农场环境的分离株中对制霉菌素耐药的菌株频率显著较低。来自人类的分离株中对卡那霉素、链霉素和新霉素耐药的菌株频率显著较高。结果显示,03和041血清群以及其他血清群的变形杆菌菌株在检测频率、对某些抗生素的耐药性以及4种耐药类型或谱的菌株比例方面存在显著差异。

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