大鼠中莽草酸的代谢
The metabolism of shikimate in the rat.
作者信息
Brewster D, Jones R S, Parke D V
出版信息
Biochem J. 1978 Feb 15;170(2):257-64. doi: 10.1042/bj1700257.
Abstract
In the rat, shikimate was metabolized and excreted as hippurate, hexahydrohippurate, 3,4,5,6-tetrahydrohippurate, t-3,t-4-dihydroxycyclohexane-r-1-carboxylate and c-3,t-4-dihydroxycyclophexane-r-1-carboxylate, conjugates of catechol and CO2. The metabolism was entirely dependent on various initial microbial transformations in the gut, metabolite formation being suppressed in animals pretreated with antibiotics. Shikimate was not metabolized by mammalian tissues, and products of microbial metabolism were excreted either unchanged or after further biotransformation in the animal tissues.
摘要
在大鼠体内，莽草酸被代谢并以马尿酸、六氢马尿酸、3,4,5,6-四氢马尿酸、反式-3,反式-4-二羟基环己烷-1-羧酸酯和顺式-3,反式-4-二羟基环己烷-1-羧酸酯、儿茶酚与二氧化碳的结合物形式排泄。这种代谢完全依赖于肠道中各种初始的微生物转化，在用抗生素预处理的动物中，代谢物的形成受到抑制。莽草酸不会被哺乳动物组织代谢，微生物代谢产物要么原样排泄，要么在动物组织中进一步生物转化后排泄。
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