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1
A new nicotinamide-adenine dinucleotide-dependent hydroaromatic dehydrogenase of Lactobacillus plantarum and its role in formation of (minus)t-3,t-4-dihydroxycyclohexane-c-1-carboxylate.植物乳杆菌一种新的烟酰胺腺嘌呤二核苷酸依赖性氢芳香脱氢酶及其在（-）-t-3，t-4-二羟基环己烷-c-1-羧酸盐形成中的作用。
Biochem J. 1974 Jul;141(1):35-42. doi: 10.1042/bj1410035.
2
(-)-3t,4t-Dihydroxycyclohexane-1c-carboxylate, a new quinate metabolite of Lactobacillus plantarum.(-)-3t,4t-二羟基环己烷-1c-羧酸盐，植物乳杆菌的一种新的奎尼酸代谢产物。
J Sci Food Agric. 1973 Aug;24(8):897-904. doi: 10.1002/jsfa.2740240806.
3
Metabolism of shikimate and quinate by Aspergillus niger and its regulation.黑曲霉对莽草酸和奎尼酸的代谢及其调控
Biochem J. 1972 Apr;127(2):15P-16P.
4
The oxidation of D-quinate and related acids by Acetomonas oxydans.氧化醋杆菌对D-奎尼酸及相关酸的氧化作用。
Biochem J. 1967 Jan;102(1):283-93. doi: 10.1042/bj1020283.
5
The role of quinate and shikimate in the metabolism of lactobacilli.奎尼酸和莽草酸在乳酸杆菌代谢中的作用。
Antonie Van Leeuwenhoek. 1971;37(1):33-49. doi: 10.1007/BF02218465.
6
Purification and characterization of a dual function 3-dehydroquinate dehydratase from Amycolatopsis methanolica.来自甲醇拟无枝酸菌的双功能3-脱氢奎尼酸脱水酶的纯化与特性分析
J Gen Microbiol. 1992 Nov;138(11):2449-57. doi: 10.1099/00221287-138-11-2449.
7
The inducible quinate-shikimate catabolic pathway in Neurospora crassa: induction and regulation of enzyme synthesis.粗糙脉孢菌中可诱导的奎尼酸-莽草酸分解代谢途径：酶合成的诱导与调控
J Gen Microbiol. 1974 Apr;81(2):357-72. doi: 10.1099/00221287-81-2-357.
8
1.6 angstroms structure of an NAD+-dependent quinate dehydrogenase from Corynebacterium glutamicum.谷氨酸棒杆菌中一种依赖NAD⁺的奎尼酸脱氢酶的1.6埃结构
Acta Crystallogr D Biol Crystallogr. 2008 Jul;D64(Pt 7):803-9. doi: 10.1107/S090744490801411X. Epub 2008 Jun 18.
9
The inducible quinate-shikimate catabolic pathway in Neurospora crassa: genetic organization.粗糙脉孢菌中可诱导的奎尼酸-莽草酸分解代谢途径：基因组织
J Gen Microbiol. 1974 Apr;81(2):337-55. doi: 10.1099/00221287-81-2-337.
10
Purification and properties of Lactobacillus plantarum inducible malic enzyme.植物乳杆菌诱导型苹果酸酶的纯化及性质
J Bacteriol. 1973 Oct;116(1):263-70. doi: 10.1128/jb.116.1.263-270.1973.

引用本文的文献

1
The metabolism of shikimate in the rat.大鼠中莽草酸的代谢
Biochem J. 1978 Feb 15;170(2):257-64. doi: 10.1042/bj1700257.

本文引用的文献

1
Case of Congenital Teratoblastoma of the Vulva (Rhabdomyoma).外阴先天性畸胎瘤（横纹肌瘤）病例
Proc R Soc Med. 1919;12(Obstet Gynaecol Sect):190-5. doi: 10.1177/003591571901200939.
2
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
3
THE MOLAR EXTINCTION COEFFICIENT OF 2,6-DICHLOROPHENOL INDOPHENOL.2,6-二氯酚靛酚的摩尔消光系数
Biochim Biophys Acta. 1964 Apr 4;86:194-7. doi: 10.1016/0304-4165(64)90180-1.
4
The reduction of quinic acid to dihydroshikimic acid by certain lactic acid bacteria.某些乳酸菌将奎尼酸还原为二氢莽草酸的过程。
Biochem J. 1957 Jun;66(2):283-5. doi: 10.1042/bj0660283.
5
Aromatic biosynthesis. XII. Conversion of 5-dehydroquinic acid to 5-dehydroshikimic acid dy 5-dehydroquinase.芳香族生物合成。十二。5-脱氢奎尼酸由5-脱氢奎尼酸酶转化为5-脱氢莽草酸。
Biochim Biophys Acta. 1954 Sep;15(1):54-61. doi: 10.1016/0006-3002(54)90093-1.
6
The oxidation of D-quinate and related acids by Acetomonas oxydans.氧化醋杆菌对D-奎尼酸及相关酸的氧化作用。
Biochem J. 1967 Jan;102(1):283-93. doi: 10.1042/bj1020283.
7
Regulation of the enzymes of the beta-ketoadipate pathway in Moraxella calcoacetica. 2. The role of protocatechuate as inducer.钙乙酸不动杆菌中β-酮己二酸途径酶的调控。2. 原儿茶酸作为诱导剂的作用。
Eur J Biochem. 1968 Jan;3(3):293-304. doi: 10.1111/j.1432-1033.1968.tb19529.x.
8
Regulation of the enzymes of the beta-ketoadipate pathway in Moraxella. Control of quinate oxidation by protocatechuate.莫拉氏菌中β-酮己二酸途径酶的调控。原儿茶酸对奎尼酸氧化的控制。
Eur J Biochem. 1970 Jul;14(3):445-50. doi: 10.1111/j.1432-1033.1970.tb00309.x.
9
The role of quinate and shikimate in the metabolism of lactobacilli.奎尼酸和莽草酸在乳酸杆菌代谢中的作用。
Antonie Van Leeuwenhoek. 1971;37(1):33-49. doi: 10.1007/BF02218465.
10
(-)-3t,4t-Dihydroxycyclohexane-1c-carboxylate, a new quinate metabolite of Lactobacillus plantarum.(-)-3t,4t-二羟基环己烷-1c-羧酸盐，植物乳杆菌的一种新的奎尼酸代谢产物。
J Sci Food Agric. 1973 Aug;24(8):897-904. doi: 10.1002/jsfa.2740240806.

植物乳杆菌一种新的烟酰胺腺嘌呤二核苷酸依赖性氢芳香脱氢酶及其在（-）-t-3，t-4-二羟基环己烷-c-1-羧酸盐形成中的作用。

A new nicotinamide-adenine dinucleotide-dependent hydroaromatic dehydrogenase of Lactobacillus plantarum and its role in formation of (minus)t-3,t-4-dihydroxycyclohexane-c-1-carboxylate.

作者信息

Whiting G C, Coggins R A

出版信息

Biochem J. 1974 Jul;141(1):35-42. doi: 10.1042/bj1410035.

DOI:10.1042/bj1410035
PMID:4375976
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1168046/
Abstract
  1. A new induced NAD-dependent hydroaromatic dehydrogenase was isolated from a cell-free extract of Lactobacillus plantarum 13a and purified 175-fold. 2. The enzyme catalyses the oxidation of (-)-quinate, (-)-shikimate, (-)-dihydroshikimate and (-)t-3,t-4-dihydroxycyclohexane-c-1-carboxylate with NAD(+), and the reverse action with NADH. 3. The K(m) values at the optimal pH10.0 for these substrates are 0.85, 0.75, 0.52 and 0.74mm respectively, and the corresponding values for NAD(+) are 0.45, 0.26, 0.34 and 0.36mm respectively. 4. The stereochemical requirements of the enzyme and the role it may play in the reduction of (-)-quinate to (-)t-3,t-4-dihydroxycyclohexane-c-1-carboxylate are discussed and a pathway is suggested.
摘要
  1. 从植物乳杆菌13a的无细胞提取物中分离出一种新的诱导型NAD依赖性氢化芳香脱氢酶，并将其纯化了175倍。2. 该酶催化(-)-奎尼酸、(-)-莽草酸、(-)-二氢莽草酸和(-)-t-3,t-4-二羟基环己烷-c-1-羧酸盐与NAD(+)的氧化反应，以及与NADH的逆反应。3. 在最佳pH10.0时，这些底物的K(m)值分别为0.85、0.75、0.52和0.74mm，NAD(+)的相应值分别为0.45、0.26、0.34和0.36mm。4. 讨论了该酶的立体化学要求及其在将(-)-奎尼酸还原为(-)-t-3,t-4-二羟基环己烷-c-1-羧酸盐中可能起的作用，并提出了一条途径。