Brewster D
Biomed Mass Spectrom. 1979 Oct;6(10):447-52. doi: 10.1002/bms.1200061009.
The biotransformation products of shikimate in the rat have been identified by electron impact mass spectrometry. Analysis of the metabolites produced after oral administration of shikimate resulted in the identification of hippurate, 3,4,5,6-tetrahydrohippurate, hexahydrohippurate, benzoyl and cyclohexylcarbonyl-beta-D-glucuronides and two isomeric 3,4-dihydroxycyclohexanecarboxylates. Results showed that shikimate itself is not metabolized by rat tissues and that all metabolites produced were dependent upon initial metabolic transformations by gastrointestinal microrganisms. The various hippurate derivatives and glucuronide conjugates appear to arise via a conversion of shikimate to cyclohexanecarboxylate, which is then further metabolized by the rat tissues.
已通过电子轰击质谱法鉴定了大鼠体内莽草酸的生物转化产物。对口服莽草酸后产生的代谢物进行分析，结果鉴定出马尿酸盐、3,4,5,6-四氢马尿酸盐、六氢马尿酸盐、苯甲酰基和环己基羰基-β-D-葡萄糖醛酸苷以及两种异构的3,4-二羟基环己烷羧酸盐。结果表明，莽草酸本身不会被大鼠组织代谢，并且产生的所有代谢物均依赖于胃肠道微生物的初始代谢转化。各种马尿酸盐衍生物和葡萄糖醛酸苷共轭物似乎是通过莽草酸转化为环己烷羧酸盐而产生的，然后再由大鼠组织进一步代谢。
