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通过微型计算机处理药代动力学数据以制定最佳药物剂型。

Pharmacokinetic data processed by microcomputer for the formulation of optimal drug dosage form.

作者信息

Aiache J M, Turlier M, Tanguy A

出版信息

Eur J Drug Metab Pharmacokinet. 1984 Apr-Jun;9(2):89-102. doi: 10.1007/BF03189611.

Abstract

Microcomputers have been used in pharmacokinetics for several years, but their use in the area of formulation is a new application. By using appropriate data on the drug, the dosage form required and its mechanism of absorption and clearance, microcomputers can systematize and speed-up formulation, simplify manufacturing processes and, through simulated models and plasma level predictions, reduce the number of bioavailability studies needed.

摘要

微型计算机已在药代动力学领域应用多年,但其在制剂领域的应用却是一项新尝试。通过运用有关药物、所需剂型及其吸收和清除机制的适当数据,微型计算机能够使制剂过程系统化并加快速度,简化生产流程,而且借助模拟模型和血药浓度预测,减少所需的生物利用度研究数量。

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