Oehmichen M, Pedal I, Besserer K, Gencic M
Forensic Sci Int. 1984 Jul;25(3):181-9. doi: 10.1016/0379-0738(84)90192-0.
In vitro evaluation of the effect of five insecticidal phosphoric and 11 thiophosphoric acid esters on different, non-specific human leukocytes esterases indicated that most of the organic phosphor compounds studied inhibited the activity of neutral alpha-naphthylacetate esterase, alpha-naphthylbutyryl esterase, and naphthol AS acetate esterase, i.e. the monocyte esterases. The extent of inhibition was dose dependent; the inhibiting dose being identical for the various non-specific esterases. Reactivation with Obidoxim was not successful. Monocyte esterase activity in a human survivor of E 605 intoxication was detectable only after serum acetylcholinesterase had returned to normal levels. The organic phosphor compound studied, however, inhibited neither acid alpha-naphthylacetate esterase nor naphthol AS-D chloroacetate esterase activity.
对5种杀虫磷酸酯和11种硫代磷酸酯作用于不同的非特异性人类白细胞酯酶的体外评估表明，所研究的大多数有机磷化合物抑制中性α-萘乙酸酯酶、α-萘丁酸酯酶和萘酚AS乙酸酯酶（即单核细胞酯酶）的活性。抑制程度呈剂量依赖性；各种非特异性酯酶的抑制剂量相同。用双复磷重新激活未成功。仅在血清乙酰胆碱酯酶恢复到正常水平后，才可检测到一名E 605中毒幸存者的单核细胞酯酶活性。然而，所研究的有机磷化合物既不抑制酸性α-萘乙酸酯酶，也不抑制萘酚AS-D氯乙酸酯酶的活性。
