有机磷酸酯与单核细胞酯酶缺乏症
Organophosphates and monocyte esterase deficiency.
作者信息
McClean E, Mackey H, Markey G M, Morris T C
机构信息
Department of Clinical Chemistry, Belfast City Hospital.
出版信息
J Clin Pathol. 1995 Aug;48(8):768-70. doi: 10.1136/jcp.48.8.768.
AIMS
To examine the possibility that monocyte esterase deficiency (MED) could be caused by exposure to organophosphates.
METHODS
Pseudocholinesterase, paraoxonase and arylesterase activities were measured in the serum and acetylcholinesterase activity was measured in the red cells of a group of monocyte esterase deficient subjects and compared with the enzyme activities of a control group of monocyte esterase positive subjects.
RESULTS
No significant difference was found between the enzyme activities of the monocyte esterase deficient group and the control group for any of the esterases investigated.
CONCLUSION
Current or recent exposure to organophosphorus is not the cause of MED.
目的
研究单核细胞酯酶缺乏症（MED）是否可能由接触有机磷酸酯引起。
方法
测定一组单核细胞酯酶缺乏受试者血清中的假性胆碱酯酶、对氧磷酶和芳基酯酶活性，并测定其红细胞中的乙酰胆碱酯酶活性，然后与单核细胞酯酶阳性的对照组受试者的酶活性进行比较。
结果
在所研究的任何一种酯酶中，单核细胞酯酶缺乏组与对照组的酶活性均未发现显著差异。
结论
当前或近期接触有机磷不是MED的病因。
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