从腹泻商品兔中分离出的大肠杆菌菌株的致病特性。
Pathogenic properties of Escherichia coli strains isolated from diarrheic commercial rabbits.
作者信息
Peeters J E, Pohl P, Okerman L, Devriese L A
出版信息
J Clin Microbiol. 1984 Jul;20(1):34-9. doi: 10.1128/jcm.20.1.34-39.1984.
Thirty-two different strains of Escherichia coli isolated from diarrheic commercial rabbits showing intestinal attachment of bacilli were studied. None of the strains produced thermostable or thermolabile enterotoxins, and none was invasive. Strains isolated from suckling rabbits attached in vitro to the brush borders of intestinal villi, whereas strains from weanling rabbits did not. After experimental infection of 5-week-old rabbits, the 26 strains isolated from weaned diarrheic rabbits attached to the epithelium of ileum, cecum, and colon, whereas only slight attachment was found after infection with the six strains isolated from suckling diarrheic rabbits. The former strains induced diarrhea in 87% of the rabbits, whereas the latter induced diarrhea in only 9% of inoculated rabbits. E. coli isolated from healthy rabbits did not cause diarrhea. Strains isolated from diarrheic suckling rabbits all belonged to serotype O109:K-:H2, whereas strains from diarrheic weaned rabbits belonged to at least eight different serogroups. It is suggested that two different mechanisms of E. coli enteropathy might exist in rabbits.
对从表现出杆菌肠道黏附的腹泻商品兔中分离出的32种不同大肠杆菌菌株进行了研究。这些菌株均未产生耐热或不耐热肠毒素，也均无侵袭性。从哺乳兔分离出的菌株在体外可黏附于肠绒毛的刷状缘，而从断奶兔分离出的菌株则不能。对5周龄兔子进行实验性感染后，从断奶腹泻兔分离出的26种菌株黏附于回肠、盲肠和结肠的上皮，而用从哺乳腹泻兔分离出的6种菌株感染后仅发现轻微黏附。前一组菌株使87%的兔子发生腹泻，而后者仅使9%的接种兔子发生腹泻。从健康兔分离出的大肠杆菌不引起腹泻。从腹泻哺乳兔分离出的菌株均属于O109:K-:H2血清型，而从腹泻断奶兔分离出的菌株至少属于八个不同的血清群。提示兔大肠杆菌肠病可能存在两种不同机制。
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