Molecular Sciences Research Center, University of Puerto Rico, San Juan, Puerto Rico; Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts; Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts;, Email:
Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts.
Comp Med. 2021 Feb 1;71(1):3-45. doi: 10.30802/AALAS-CM-20-000054. Epub 2021 Jan 8.
is one of the most common species of bacteria colonizing humans and animals. The singularity of 's genus and species underestimates its multifaceted nature, which is represented by different strains, each with different combinations of distinct virulence factors. In fact, several pathotypes, or hybrid strains, may be associated with both subclinical infection and a range of clinical conditions, including enteric, urinary, and systemic infections. may also express DNA-damaging toxins that could impact cancer development. This review summarizes the different pathotypes in the context of their history, hosts, clinical signs, epidemiology, and control. The pathotypic characterization of in the context of disease in different animals, including humans, provides comparative and One Health perspectives that will guide future clinical and research investigations of infections.
是一种最常见的定植于人类和动物的细菌之一。 属和种的单一性低估了其多面性，这种多面性表现为不同的菌株，每个菌株都有不同组合的独特毒力因子。事实上，有几种 血清型或混合菌株可能与亚临床感染和一系列临床病症相关，包括肠道、泌尿道和全身感染。 也可能表达破坏 DNA 的毒素，这些毒素可能会影响癌症的发展。本综述总结了不同血清型在其历史、宿主、临床症状、流行病学和控制方面的情况。在不同动物（包括人类）疾病背景下对 血清型的特征描述提供了比较和“One Health”视角，这将指导未来对 感染的临床和研究调查。
