Saarinen U M
J Allergy Clin Immunol. 1984 Aug;74(2):196-200. doi: 10.1016/0091-6749(84)90286-0.
A previously healthy 8-year old girl was diagnosed with acute myelogenous leukemia, and, while she was in first remission, she received a bone marrow transplant from her atopic brother. Studies 1 to 2 years after transplantation revealed that the marrow recipient had a specific-IgE production of donor-type pattern, indicated by the similar skin prick test results and RAST scores in the donor and recipient demonstrating allergy to animal dander and house dust. The recipient's own immunity had been destroyed by the preparative regimen for marrow transplantation, and no lymphoid cells of host origin could be found after transplantation in the chromosome analysis. A sensitization of the recipient to animal dander after transplantation was very unlikely because no animal contacts were present, and the chronic liver graft-versus-host disease of the patient additionally suggested a delayed immunologic recovery. The case history suggests that atopy can be transferred by bone marrow transplantation from donor to recipient. A possible mechanism appears to be a passive transfer not only of lymphoid precursors but also of mature memory cells within the bone marrow inoculum. The donor memory B cells are presumably capable of starting specific-IgE production when the cells are stimulated in the host environment by factors still unknown.
一名此前健康的8岁女孩被诊断出患有急性髓细胞白血病，在首次缓解期时，她接受了来自患有特应性疾病的哥哥的骨髓移植。移植后1至2年的研究显示，骨髓接受者产生了供体类型模式的特异性IgE，供体和接受者相似的皮肤点刺试验结果和放射性变应原吸附试验（RAST）评分表明他们对动物皮屑和屋尘过敏。骨髓移植的预处理方案破坏了接受者自身的免疫力，染色体分析显示移植后未发现宿主来源的淋巴细胞。由于没有接触动物，移植后接受者对动物皮屑致敏的可能性极小，而且患者的慢性移植物抗宿主病进一步表明免疫恢复延迟。该病例史表明，特应性疾病可通过骨髓移植从供体转移至受体。一种可能的机制似乎不仅是淋巴细胞前体的被动转移，还包括骨髓接种物中成熟记忆细胞的被动转移。当供体记忆B细胞在宿主环境中受到仍未知的因素刺激时，大概能够启动特异性IgE的产生。
