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一项关于舒林酸与萘普生治疗老年骨关节炎患者的多中心研究。

A multi-centre study of sulindac versus naproxen in the treatment of elderly osteoarthritic patients.

作者信息

Janke P G, Diggins J B, Currie W J, Dasgupta P K, Glick E N, Sheikh N A

出版信息

Pharmatherapeutica. 1984;3(10):663-7.

PMID:6379679
Abstract

Ninety-five geriatric patients with osteoarthritis of the hip and/or knee were entered into an open parallel group study of sulindac (400 mg/day) and naproxen (500 mg/day), both given in twice-daily regimens. Patients received the drugs for 12 weeks. Both drugs produced improvements in the patients' overall condition. There were no statistically significant differences between the effects of the two drugs. Overall, both drugs proved beneficial and well tolerated.

摘要

95名患有髋部和/或膝部骨关节炎的老年患者参与了一项关于舒林酸(400毫克/天)和萘普生(500毫克/天)的开放性平行组研究,两种药物均采用每日两次的给药方案。患者接受药物治疗12周。两种药物均使患者的整体状况得到改善。两种药物的疗效之间没有统计学上的显著差异。总体而言,两种药物都证明是有益的且耐受性良好。

相似文献

1
A multi-centre study of sulindac versus naproxen in the treatment of elderly osteoarthritic patients.一项关于舒林酸与萘普生治疗老年骨关节炎患者的多中心研究。
Pharmatherapeutica. 1984;3(10):663-7.
2
Naproxen and sulindac in the treatment of osteoarthritis of the hip and knee.萘普生和舒林酸治疗髋和膝骨关节炎
Rheumatol Rehabil. 1981 Aug;20(3):184-7. doi: 10.1093/rheumatology/20.3.184.
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Osteoarthritis and non-steroidal and anti-inflammatory drugs: a multi-centre comparative study.
Curr Med Res Opin. 1982;7(Suppl 1):41-52.
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Symptomatic osteoarthritis in the elderly: a comparative study of sulindac and ibuprofen.
Curr Med Res Opin. 1982;7(Suppl 1):33-40.
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[Comparison of the analgesic and anti-inflammatory effects of diclofenac, sulindac and naproxen. Multicentric double blind study].
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Differential effects of two non steroidal anti-inflammatory drugs on the plasma urea of elderly patients with osteoarthritis. A multicentre study.两种非甾体抗炎药对老年骨关节炎患者血浆尿素的不同影响。一项多中心研究。
Br J Clin Pract. 1984 Nov-Dec;38(11-12):403-6.
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A comparison of benoxaprofen and sulindac in patients with rheumatoid arthritis and osteoarthritis.类风湿性关节炎和骨关节炎患者中苯恶洛芬与舒林酸的比较。
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引用本文的文献

1
Pharmacokinetics of naproxen in elderly patients.萘普生在老年患者中的药代动力学。
Eur J Clin Pharmacol. 1986;31(4):463-8. doi: 10.1007/BF00613525.
2
Naproxen. A reappraisal of its pharmacology, and therapeutic use in rheumatic diseases and pain states.萘普生。对其药理学以及在风湿性疾病和疼痛状态中的治疗用途的重新评估。
Drugs. 1990 Jul;40(1):91-137. doi: 10.2165/00003495-199040010-00006.