Todd P A, Clissold S P
Adis Drug Information Services, Auckland, New Zealand.
Drugs. 1990 Jul;40(1):91-137. doi: 10.2165/00003495-199040010-00006.
Naproxen is a nonsteroidal anti-inflammatory drug (NSAID) advocated for use in painful and inflammatory rheumatic and certain nonrheumatic conditions. It may be administered orally or rectally using a convenient once or twice daily regimen. Dosage adjustments are not usually required in the elderly or those with mild renal or hepatic impairment although it is probably prudent to start treatment at a low dosage and titrate upwards in such groups of patients. Numerous clinical trials have confirmed that the analgesic and anti-inflammatory efficacy of naproxen is equivalent to that of the many newer and established NSAIDs with which it has been compared. The drug is effective in many rheumatic diseases such as rheumatoid arthritis, osteoarthritis, ankylosing spondylitis and nonarticular rheumatism, in acute traumatic injury, and in the treatment of and prophylaxis against acute pain such as migraine, tension headache, postoperative pain, postpartum pain and pain associated with a variety of gynaecological procedures. Naproxen is also effective in treating the pain and associated symptoms of primary or secondary dysmenorrhoea, and decreases excessive blood loss in patients with menorrhagia. The adverse effect profile of naproxen is well established, particularly compared with that of many newer NSAIDs, and the drug is well tolerated. Thus, the efficacy and tolerability of naproxen have been clearly established over many years of clinical use, and it can therefore be considered as a first-line treatment for rheumatic diseases and various pain states.
萘普生是一种非甾体抗炎药（NSAID），被推荐用于治疗疼痛性和炎性风湿性疾病以及某些非风湿性疾病。它可以口服或直肠给药，采用方便的每日一次或两次给药方案。对于老年人或轻度肾或肝功能损害的患者，通常不需要调整剂量，不过在这类患者群体中，开始治疗时采用低剂量并逐渐增加剂量可能更为谨慎。大量临床试验证实，萘普生的镇痛和抗炎效果与许多已与其进行比较的新型和老牌NSAID相当。该药物对许多风湿性疾病有效，如类风湿关节炎、骨关节炎、强直性脊柱炎和非关节性风湿病，对急性创伤性损伤有效，还可用于治疗和预防急性疼痛，如偏头痛、紧张性头痛、术后疼痛、产后疼痛以及与各种妇科手术相关的疼痛。萘普生在治疗原发性或继发性痛经的疼痛及相关症状方面也有效，并且可减少月经过多患者的失血。萘普生的不良反应情况已得到充分证实，特别是与许多新型NSAID相比，该药物耐受性良好。因此，萘普生的疗效和耐受性在多年的临床应用中已得到明确证实，故而可被视为风湿性疾病和各种疼痛状态的一线治疗药物。
