干燥综合征的泪腺和唾液分泌：氨溴索全身治疗的效果

Lacrimal and salivary secretion in Sjögren's syndrome: the effect of systemic treatment with bromhexine.

作者信息

Prause J U, Frost-Larsen K, Høj L, Isager H, Manthorpe R

出版信息

Acta Ophthalmol (Copenh). 1984 Jun;62(3):489-97. doi: 10.1111/j.1755-3768.1984.tb08430.x.

DOI:10.1111/j.1755-3768.1984.tb08430.x

Abstract

In a randomized clinical study, 32 patients with Sjögrens syndrome (SS) were given placebo/bromhexine (Bisolvon) 48 mg daily for 3 weeks. Various ophthalmological and oral variables as well as different proteins in tear fluid and saliva were registered. Bromhexine stimulated the tear secretion significantly, presumably without changing the protein composition of the tear fluid. In saliva the IgM concentration in contrast to other proteins decreased in patients with high pre-treatment values. Bromhexine may be of valuable help in the treatment of some patients with SS.

摘要

在一项随机临床研究中，32名干燥综合征（SS）患者每天服用安慰剂/溴己新（必嗽平）48毫克，持续3周。记录了各种眼科和口腔变量以及泪液和唾液中的不同蛋白质。溴己新显著刺激泪液分泌，可能不会改变泪液的蛋白质组成。相比之下，在治疗前IgM浓度较高的患者唾液中，与其他蛋白质相比，IgM浓度降低。溴己新可能对一些SS患者的治疗有宝贵帮助。