Larkin R M, Van Orden D E, Poulson A M, Scott J R
Obstet Gynecol. 1979 Oct;54(4):456-60.
Painful menses, one of the most frequent gynecologic complaints, is incapacitating for many women. It has recently been proposed that increased endometrial prostaglandin production and prostaglandin-induced myometrial contractility may be responsible for dysmenorrhea. In this prospective, double-blind, 3-way, crossover study, relief of pain by an antiprostaglanding drug, ibuprofen (400 mg), was compared with propoxyphene (64 mg) and placebo in 22 women with severe primary dysmenorrhea. Ibuprofen was significantly more effective in 18 patients when compared to the other 2 treatment regimens (P less than 0.001), while propoxyphene was superior to placebo in 13 patients (P less than 0.05). Prostaglandin E and F synthesis rates in endometrial biopsy specimens taken on the second day of treatment in 2 patients during each treatment cycle were lowest during ibuprofen in one case but showed no definite pattern in the second.
痛经是最常见的妇科病症之一，许多女性深受其苦。最近有人提出，子宫内膜前列腺素生成增加以及前列腺素诱导的子宫肌层收缩可能是痛经的病因。在这项前瞻性、双盲、三向交叉研究中，对22名患有严重原发性痛经的女性，比较了一种抗前列腺素药物布洛芬（400毫克）与丙氧芬（64毫克）及安慰剂缓解疼痛的效果。与其他两种治疗方案相比，布洛芬对18名患者的疗效显著更佳（P小于0.001），而丙氧芬对13名患者的疗效优于安慰剂（P小于0.05）。在每个治疗周期的第二天，对2名患者进行子宫内膜活检标本检测，其中1例患者在服用布洛芬期间，前列腺素E和F的合成率最低，但另一例患者未呈现明确规律。
