Prigatano G P, Wright E C, Levin D
Arch Intern Med. 1984 Aug;144(8):1613-9.
Measures of quality of life were obtained on 985 patients with mild hypoxemia and chronic obstructive pulmonary disease (COPD). A subsample of 100 patients were also given extensive neuropsychological and personality tests. Mildly hypoxemic COPD patients showed impairment in quality-of-life activities. They showed less impairment in physical function, compared with previous studies on COPD patients with hypoxemia, but about equal impairment in psychosocial function and dysphoric mood. Nonrelated health changes in life do not seem to account for these findings. Degree of self-reported tension-anxiety was the single greatest predictor of both physical and psychosocial measures of quality of life. Level of exercise completed, forced expiratory volume in 1 s, and neuropsychological status were significantly related to physical limitations, but not psychosocial functioning. The Pao2 was not significantly related to quality-of-life measures in this patient group.
对985例轻度低氧血症和慢性阻塞性肺疾病（COPD）患者进行了生活质量评估。还对100例患者的子样本进行了广泛的神经心理学和人格测试。轻度低氧血症的COPD患者在生活质量活动方面存在损害。与先前对低氧血症COPD患者的研究相比，他们在身体功能方面的损害较小，但在心理社会功能和烦躁情绪方面的损害大致相同。生活中无关的健康变化似乎无法解释这些发现。自我报告的紧张焦虑程度是生活质量身体和心理社会指标的唯一最大预测因素。完成的运动水平、1秒用力呼气量和神经心理状态与身体限制显著相关，但与心理社会功能无关。在该患者组中，动脉血氧分压与生活质量指标无显著相关性。
