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慢性阻塞性肺疾病患者的抑郁、焦虑和惊恐障碍:与烟草使用、疾病严重程度及生活质量的相关性

Depression, anxiety and panic disorders in chronic obstructive pulmonary disease patients: correlations with tobacco use, disease severity and quality of life.

作者信息

Pascal Oana Irinel, Trofor Antigona Carmen, Lotrean Lucia Maria, Filipeanu Dumitru, Trofor Letitia

机构信息

"Grigore T. Popa" University of Medicine and Pharmacy Iasi, No 16 Universitatii Street, 700115 Iasi, Romania.

"Iuliu Hatieganu" University of Medicine and Pharmacy Cluj-Napoca, No 8 Victor Babeş Street, 400012 Cluj-Napoca, Romania.

出版信息

Tob Induc Dis. 2017 Apr 7;15:23. doi: 10.1186/s12971-017-0128-9. eCollection 2017.

Abstract

BACKGROUND

The objective of this study is to assess anxiety, depression and panic disorders among patients diagnosed with COPD and to investigate their correlation with disease severity, quality of life as well as tobacco use.

METHODS

An observational study was performed between January and September 2014 among 60 patients diagnosed with COPD. COPD staging according to GOLD criteria, while anxiety and depression were assessed using Hospital Anxiety and Depression Scale and panic attacks were evaluated based on ICD 10 criteria.

RESULTS

Almost 40% of the sample were smokers, the medium packs-years was 34.3 and the medium Fagerstrom score was 7.5. Overall, mean Modified Medical Research Council Dyspnea Scale (mMRC) was 2.86, mean COPD Assessment Test (CAT) score was 21.75 and study participants had 1.93 COPD exacerbations/year. Mean distribution of anxiety and depression symptoms scores among COPD subjects was 10.65 ± 3.5 and 9.93 ± 3.8, respectively. Smokers and ex-smokers had similar scores with regard to anxiety, depression or the presence of panic attacks. The results of the bivariate correlations indicated associations between anxiety, depression, panic attacks and disease severity, as well as poor quality of life of patients with COPD, regardless of their current tobacco use status.

CONCLUSIONS

In conclusion, the results of this study indicate that anxiety, depression and panic attacks were constant characteristics among COPD patients- regardless of their current tobacco use.

摘要

背景

本研究的目的是评估慢性阻塞性肺疾病(COPD)患者的焦虑、抑郁和惊恐障碍,并调查它们与疾病严重程度、生活质量以及烟草使用之间的相关性。

方法

2014年1月至9月期间对60例确诊为COPD的患者进行了一项观察性研究。根据全球慢性阻塞性肺疾病倡议(GOLD)标准对COPD进行分期,使用医院焦虑抑郁量表评估焦虑和抑郁情况,并根据国际疾病分类第10版(ICD 10)标准评估惊恐发作。

结果

近40%的样本为吸烟者,平均吸烟包年数为34.3,平均法格斯屈姆评分(Fagerstrom score)为7.5。总体而言,改良医学研究委员会呼吸困难量表(mMRC)的平均值为2.86,慢性阻塞性肺疾病评估测试(CAT)的平均得分为21.75,研究参与者每年有1.93次慢性阻塞性肺疾病急性加重。慢性阻塞性肺疾病患者中焦虑和抑郁症状评分的平均分布分别为10.65±3.5和9.93±3.8。吸烟者和戒烟者在焦虑、抑郁或惊恐发作方面的得分相似。双变量相关性结果表明,无论患者当前的烟草使用状况如何,焦虑、抑郁、惊恐发作与疾病严重程度以及慢性阻塞性肺疾病患者的生活质量差之间均存在关联。

结论

总之,本研究结果表明,焦虑、抑郁和惊恐发作是慢性阻塞性肺疾病患者的常见特征,无论他们当前的烟草使用情况如何。

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