Friedman-Birnbaum R, Haim S, Gideone O, Barzilai A
Br J Dermatol. 1978 Apr;98(4):425-8.
Thirteen patients with localized granuloma annulare and 19 with the generalized form of the disease were typed for HLA antigens. The control group consisted of 70 matched apparently healthy subjects. No significant difference in the frequencies of the 26 tested antigens was revealed between patients with localized granuloma annulare and controls. Patients with the generalized form of the disease showed a highly significant increase in the frequency of HLA-Bw35 as compared with both controls and patients with the localized form of the disorder (P = 0.001 and 0.01 respectively). The results seem suggestive of a possible different pathogenesis of the two forms of the disease.
对13例局限性环状肉芽肿患者和19例全身性环状肉芽肿患者进行了HLA抗原分型。对照组由70名匹配的表面健康的受试者组成。局限性环状肉芽肿患者与对照组之间，在26种检测抗原的频率上未发现显著差异。全身性环状肉芽肿患者与对照组及局限性环状肉芽肿患者相比，HLA - Bw35频率显著升高（分别为P = 0.001和0.01）。结果似乎提示这两种形式的疾病可能有不同的发病机制。
